Oral manifestations of hydroa vacciniforme-like lymphoproliferative disorder: a clinicopathological study of a peruvian population

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dc.creatorCinthia Veronica Bardalez Lopez de Caceres
dc.creatorCarla Isabelly Rodrigues-Fernandes
dc.creatorJavier Rendón Henao
dc.creatorThayná Melo de Lima Morais
dc.creatorCiro Dantas Soares
dc.creatorOslei Paes de Almeida
dc.creatorFelipe Paiva Fonseca
dc.creatorWilson Delgado-Azañero
dc.date.accessioned2023-12-20T18:58:26Z
dc.date.accessioned2025-09-08T23:53:17Z
dc.date.available2023-12-20T18:58:26Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.1111/jop.13203
dc.identifier.issn16000714
dc.identifier.urihttps://hdl.handle.net/1843/62114
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of oral pathology & medicine
dc.rightsAcesso Restrito
dc.subjectEpstein-Barr virus infections
dc.subjectHydroa vacciniforme
dc.subjectLymphoma, T-cell
dc.subjectImmunohistochemistry
dc.subjectT-lymphocytes, cytotoxic
dc.subject.otherbusca dia 22 do mes 11 novembro ano 2023
dc.subject.othertítulo periódico Journal of oral pathology & medicine (online)
dc.titleOral manifestations of hydroa vacciniforme-like lymphoproliferative disorder: a clinicopathological study of a peruvian population
dc.typeArtigo de periódico
local.citation.epage539
local.citation.issue6
local.citation.spage530
local.citation.volume50
local.description.resumoBackground: Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is a chronic Epstein-Barr virus (EBV)-positive lymphoproliferative disease which may either present as an indolent condition or progress to a systemic T-cell lymphoma. Methods: All HVLPD diagnosed over a 10-year period were retrieved, and clinical data regarding sex, age, oral and systemic manifestations, and clinical follow-up were obtained. Immunohistochemistry was done in order to characterize the lymphoid cells, and in situ hybridization was used to demonstrate the presence of EBV. Results: Eleven cases were included, with a male predominance and a mean age of 25.1 years. Buccal mucosa and the lips were the most affected oral sites, appearing as painful ulcers. All patients exhibited facial oedema, usually affecting the lips, nose and periorbital region. The clinical course was gradual but progressive, with four patients having fever and 3 showing lymphadenopathies. All cases showed a moderate to severe lymphocytic infiltrate with angiotropism, angiocentricity and epidermotropism. Two cases affecting the lip skin exhibited a periappendageal lymphocytic infiltrate. Few large pleomorphic cells were found, surrounded by smaller and medium-sized lymphoid cells, as well as reactive plasma cells, macrophages, neutrophils and eosinophils. All lesions exhibited a cytotoxic T-cell (CD8+) phenotype with a variable proliferative index. All cases were associated with EBV, and all patients died due to complications of the disease. Conclusions: HVLPD is a rare disease that may show oral involvement with a cytotoxic T-cell phenotype, and is strongly associated with EBV. As shown in this series, HVLPD may show aggressive clinical behaviour.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13203

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