Effects of omentectomy in addition to sleeve gastrectomy on the metabolic and inflammatory profiles of obese rats

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dc.creatorThaísa Soares Crespo
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorAntônio Sérgio Barcala Jorge
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luís Sena Guimarães
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2022-08-12T12:00:42Z
dc.date.accessioned2025-09-08T23:10:35Z
dc.date.available2022-08-12T12:00:42Z
dc.date.issued2016-08
dc.identifier.doihttps://doi.org/10.1016/j.soard.2016.01.026
dc.identifier.issn1550-7289
dc.identifier.urihttps://hdl.handle.net/1843/44215
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofSurgery for Obesity and Related Diseases
dc.rightsAcesso Aberto
dc.subjectObesidade
dc.subjectGastrectomia
dc.subjectCirurgia bariátrica
dc.subjectEmagrecimento
dc.subjectInflamação
dc.titleEffects of omentectomy in addition to sleeve gastrectomy on the metabolic and inflammatory profiles of obese rats
dc.typeArtigo de periódico
local.citation.epage1299
local.citation.issue7
local.citation.spage1292
local.citation.volume12
local.description.resumoBackground: visceral obesity has been considered a risk factor for metabolic and cardiovascular complications. In an attempt to reduce the visceral adipose tissue, omentectomy has been proposed to be performed along with bariatric surgery. Objective: the goal of this study was to evaluate whether omentectomy associated with sleeve gastrectomy (SG) is beneficial to the inflammatory and metabolic profile of rats fed a standard diet (STD) or high-fat diet (HFD). Setting: University hospital, Brazil. Methods: for this experiment, male Wistar rats were randomly divided into 6 groups as follows: sham surgery (STD+L or HFD+L), SG alone (STD+SG or HFD+SG), or SG with omentectomy (STD+SGO or HFD+SGO). Anthropometric data and metabolic profiles were evaluated, and the tissue expression of inflammatory markers in the visceral adipose tissue was measured. Results: in rats with diet-induced obesity treated with SG with or without omentectomy, there was a reduction in weight (HFD+SG: P<.01 and HFD+SGO: P<.05), adiposity (HFD+SG: P<.001 and HFD+SGO: P<.05), plasma levels of glucose (HFD+SG: P<.01 and HFD+SGO: P<.01), plasma levels of C-peptide (HFD+SG: P<.01 and HFD+SGO: P<.001), plasma levels of insulin (HFD+SG: P<.05 and HFD+SGO: P<.001), plasma levels of total cholesterol (HFD+SG: P<.01 and HFD+SGO: P<.01), and tissue expression of TNF-α (HFD+SG: P<.001 and HFD+SGO: P<.01), but there was no statistically significant difference between the groups in which omentectomy was performed or was not. Conclusion: in this study, we did not observe additional beneficial effects due to omentectomy associated with SG in the metabolic profile and tissue expression of inflammatory markers.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1550728916000319?via%3Dihub

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