Decoding the influence of the immune system and immunotherapy targets on carcinomas: a hidden prism in oral cancer therapy

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dc.creatorVasantha Dhara
dc.creatorThilak P.S. Gopinath
dc.creatorSameep S. Shetty
dc.creatorJosé Alcides Almeida de Arruda
dc.creatorTarcília Aparecida da Silva
dc.creatorRemo Castro Russo
dc.creatorNeetha J. Shetty
dc.creatorManasa Pidaparthi
dc.creatorBarbara Wollenberg
dc.creatorVishal U.S. Rao
dc.date.accessioned2025-05-08T19:27:44Z
dc.date.accessioned2025-09-09T01:17:16Z
dc.date.available2025-05-08T19:27:44Z
dc.date.issued2023-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.disamonth.2022.101353
dc.identifier.issn1557-8194
dc.identifier.urihttps://hdl.handle.net/1843/82148
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofDisease-a-Month
dc.rightsAcesso Restrito
dc.subjectImmune system
dc.subjectImmunosuppression therapy
dc.subjectInflammation
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectTumor microenvironment
dc.subject.otherImmune system
dc.subject.otherImmunotherapy
dc.subject.otherInflammation
dc.subject.otherOral oncology
dc.subject.otherOral squamous cell carcinoma
dc.subject.otherTumor microenvironment
dc.titleDecoding the influence of the immune system and immunotherapy targets on carcinomas: a hidden prism in oral cancer therapy
dc.typeArtigo de periódico
local.citation.issue1
local.citation.spage101353
local.citation.volume69
local.description.resumoIn recent decades, understanding tumorigenesis and the complex interaction between the host and the immune system has been the pillar for significant advances in anticancer therapy. Conventional anticancer therapy (e.g., cut, burn, and cytotoxic drugs) involves multiple targeting of tumor cells. However, the tumor tissue microenvironment can present a dysregulated, stimulating, or subverted immune response which, in turn, reveals pro-tumor activities favoring tumor expansion and progression. Recently, new potential targets have been identified based on immunomodulatory therapies, which are crafted to re-establish the host anti-tumoral immune response. Clinicians should fully understand the intricate interactions between carcinogens, the tumor milieu, the immune system, and traditional anticancer therapies in order to progress and to overcome the refractory/recurrent challenges and morbidity of the disease. Thus, in this article, we highlight the complex milieu of the oral cancer immune response, pointing out potential therapeutic immunotargets for oral squamous cell carcinomas. The impact of traditional anticancer therapy on the immune system is also outlined.
local.identifier.orcidhttps://orcid.org/0000-0001-8841-6235
local.identifier.orcidhttps://orcid.org/0000-0003-4312-8322
local.identifier.orcidhttps://orcid.org/0000-0002-7625-7289
local.identifier.orcidhttps://orcid.org/0000-0001-8729-9348
local.identifier.orcidhttps://orcid.org/0000-0002-6599-3950
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-1715-3834
local.identifier.orcidhttps://orcid.org/0000-0001-6167-5114
local.identifier.orcidhttps://orcid.org/0000-0002-3062-459X
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0011502922000372?via%3Dihub

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