Histochemical analysis of collagen fibers in giant cell fibroma and inflammatory fibrous hyperplasia

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dc.creatorMônica Jarema Schmidt
dc.creatorAntonio Adilson Soares de Lima
dc.creatorTeixeira Suelen Luiz
dc.creatorArielli Carine Michels
dc.creatorMaria Cássia Ferreira Aguiar
dc.creatorAline Cristina Batista Rodrigues Johann
dc.creatorAndré Tschoeke
dc.creatorLúcia Noronha
dc.creatorRafaela Scariot de Moraes
dc.creatorRicardo Alves de Mesquita
dc.creatorAna Maria Trindade Grégio
dc.creatorLuciana Reis Azevedo Alanis
dc.creatorSérgio Aparecido Ignácio
dc.creatorJean Nunes dos Santos
dc.date.accessioned2024-10-01T22:29:02Z
dc.date.accessioned2025-09-08T23:37:57Z
dc.date.available2024-10-01T22:29:02Z
dc.date.issued2016-06
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.acthis.2016.04.007
dc.identifier.issn: 1618-0372
dc.identifier.urihttps://hdl.handle.net/1843/77109
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofActa Histochemica
dc.rightsAcesso Restrito
dc.subjectFibroma
dc.subjectCollagen
dc.subjectMouth mucosa
dc.subjectHyperplasia
dc.subjectNeoplasms
dc.subject.otherFibroma
dc.subject.otherPicrosirius red
dc.subject.otherCollagen
dc.titleHistochemical analysis of collagen fibers in giant cell fibroma and inflammatory fibrous hyperplasia
dc.typeArtigo de periódico
local.citation.epage455
local.citation.issue5
local.citation.spage451
local.citation.volume118
local.description.resumoObjective The aim was to investigate collagen fibers in giant cell fibroma, inflammatory fibrous hyperplasia, and oral normal mucosa. Materials and methods Sixty-six cases were stained with picrosirius red. The slides were observed under polarization, followed by the measurement of the area and the percentage of the type I and type III collagens. The age and gender were obtained from the clinical records. Results No differences could be observed in both the area and percentage of the type I and type III collagens within the categories of lesions and normal mucosa. In the giant cells fibroma, a greater area and percentage of type I collagen could be identified in individuals of less than 41.5 years (p < 0.05). Conclusion The distribution of type I and type III collagen fibers in the studied lesions followed a similar pattern to that observed in the normal mucosa, indicating a normal collagen maturation process of type III to I. The study supports that multinucleated and stellate cells of the giant cell fibroma appear to be functional within collagen types III and I turnover. The greater amount of type I collagen identified in giant cell fibroma in individuals of less than 41.5 years reinforce the neoplastic nature of lesion.
local.identifier.orcidhttps://orcid.org/0000-0002-4911-6413
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.identifier.orcidhttps://orcid.org/0000-0001-8809-3579
local.identifier.orcidhttps://orcid.org/0000-0002-8242-3781
local.identifier.orcidhttps://orcid.org/0000-0002-9522-6832
local.identifier.orcidhttps://orcid.org/0000-0001-5675-8134
local.identifier.orcidhttps://orcid.org/0000-0001-5134-3466
local.identifier.orcidhttps://orcid.org/0000-0002-1678-9363
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0065128116300642#:~:text=The%20aim%20was%20to%20investigate%20collagen%20fibers%20in%20giant%20cell

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