Comparative study of the synovial levels of RANKL and OPG in rheumatoid arthritis, spondyloarthritis and osteoarthritis

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dc.creatorThaíse Oliveira Quaresma
dc.creatorSérgio Couto Luna de Almeida
dc.creatorTarcília Aparecida da Silva
dc.creatorPaulo Louzada-Júnior
dc.creatorRenê Donizeti Ribeiro de Oliveira
dc.date.accessioned2025-05-19T20:08:32Z
dc.date.accessioned2025-09-08T23:10:21Z
dc.date.available2025-05-19T20:08:32Z
dc.date.issued2023
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1186/s42358-023-00294-3
dc.identifier.issn2523-3106
dc.identifier.urihttps://hdl.handle.net/1843/82348
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAdvances in rheumatology
dc.rightsAcesso Aberto
dc.subjectArthritis
dc.subjectArthritis, rheumatoid
dc.subjectSpondylarthropathies
dc.subjectOsteoarthritis
dc.subjectRANK ligand
dc.subjectProteins
dc.subject.otherArthritides
dc.subject.otherRheumatoid arthritis
dc.subject.otherSpondyloarthropathy
dc.subject.otherOsteoarthrosis
dc.subject.otherOPGL protein
dc.subject.otherRANKL protein
dc.titleComparative study of the synovial levels of RANKL and OPG in rheumatoid arthritis, spondyloarthritis and osteoarthritis
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue13
local.citation.spage1
local.citation.volume63
local.description.resumoIntroduction: In chronic arthropathies, there are several mechanisms of joint destruction. In recent years, studies have reported the implication of receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG) in the process of activation and differentiation of osteoclasts, a key cell in the development of bone erosion. The RANKL/OPG ratio is increased in the serum of patients with malignant diseases and lytic bone disease, as well as rheumatoid arthritis (RA). The objective of this study was to measure and compare the concentrations of OPG and RANKL in the synovial fluid (SF) of patients with rheumatoid arthritis, spondyloarthritis (SpA) and osteoarthritis (OA). Methods: This was an observational and cross-sectional study with 83 patients, 33 with RA, 32 with SpA and 18 with OA, followed up regularly in the outpatient clinics of the Rheumatology Department of the Clinics Hospital of the Ribeirão Preto Medical School-USP. All patients were assessed for indications for arthrocentesis by the attending physicians at the time of SF collection and were evaluated for demographic variables and medication use. Disease activity was assessed in individuals with RA and SpA. The quantification of SF OPG and RANKL levels was performed by ELISA, and the correlations of the results with clinical, laboratory and radiological parameters were assessed. Results: We found no statistically significant difference in the RANKL and OPG levels among the groups. Patients with RA showed a positive correlation between the SF cell count and RANKL level (r = 0.59; p < 0.05) and the RANKL/OPG ratio (r = 0.55; p < 0.05). Patients with OA showed a strong correlation between C-reactive protein (CRP) and the RANKL/OPG ratio (r = 0.82; p < 0.05). There was no correlation between the OPG and RANKL levels and markers of inflammatory activity or the disease activity index in patients with RA or SpA. Conclusion: Within this patient cohort, the RANKL/OPG ratio was correlated with the SF cell count in patients with RA and with serum CRP in patients with OA, which may suggest a relationship with active inflammation and more destructive joint disease.
local.identifier.orcidhttps://orcid.org/0000-0002-0099-0337
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0003-2585-3870
local.identifier.orcidhttps://orcid.org/0000-0003-0229-6864
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentMEDICINA - FACULDADE DE MEDICINA
local.publisher.initialsUFMG
local.url.externahttps://advancesinrheumatology.biomedcentral.com/articles/10.1186/s42358-023-00294-3

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