Efficient cutaneous wound healing using bixin-loaded PCL nanofibers in diabetic mice

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dc.creatorAna Delia Pinzón García
dc.creatorPuebla Cassini Vieira
dc.creatorCyntia Cabral Ribeiro
dc.creatorCarlos Eduardo de Matos Jensen
dc.creatorLuciola Silva Barcelos
dc.creatorMaría Esperanza Cortés Segura
dc.creatorRubén Dario Sinisterra Millán
dc.date.accessioned2023-11-23T18:43:56Z
dc.date.accessioned2025-09-08T22:55:57Z
dc.date.available2023-11-23T18:43:56Z
dc.date.issued2017-10
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.identifier.doihttps://doi.org/10.1002/jbm.b.33724
dc.identifier.issn1552-4981
dc.identifier.urihttps://hdl.handle.net/1843/61314
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Biomedical Materials Research Part B: Applied Biomaterials
dc.rightsAcesso Restrito
dc.subjectCicatrização de feridas
dc.subjectDiabetes
dc.subjectCarotenoides
dc.subjectCondutividade elétrica
dc.subjectEspectroscopia de infravermelho
dc.subjectRaios X - Difração
dc.subjectAnálise térmica
dc.subjectMicroscopia eletrônica de varredura
dc.subject.otherBixin
dc.subject.otherPolymeric nanofiber
dc.subject.otherWound healing
dc.subject.otherDiabetes mellitus
dc.subject.otherPolycaprolactone (PCL)
dc.titleEfficient cutaneous wound healing using bixin-loaded PCL nanofibers in diabetic mice
dc.typeArtigo de periódico
local.citation.epage1949
local.citation.issue7
local.citation.spage1938
local.citation.volume105
local.description.resumoThe present work demonstrated an efficient cutaneous wound healing using Bixin-loaded polycaprolactone (PCL) nanofibers as a controlled delivery system. The influence of Bixin (Bix) content on PCL nanofiber, Bix-PCL1(2.5% w/w bix) and Bix-PCL2 (12.5% w/w bix) formation was investigated using electrical conductivity, attenuated total reflectance infrared spectroscopy, X-ray diffraction, thermal analysis, and scanning electronic microscopy. The results showed that a greater bixin concentration resulted in higher polymeric solution electrical conductivity. Moreover, higher polymeric solution electrical conductivity provides lower nanofibers in terms of average diameter than pure PCL nanofibers. In vitro release was largely governed by a diffusion-controlled mechanism. The initial Bixin release domain showed a burst release over the first 10 hours where approximately 30% and 40% of Bixin was released from Bix-PCL1 and Bix-PCL2 nanofibers, respectively. The second kinetic domain was comprised of a continuous and slow Bixin release that led to almost 100% of the Bixin being released within 14 days. The results on excisional wound model in induced diabetic mice indicated that the low concentration of Bixin released from loaded Bix-PCL nanofibers maintain the biological activity of Bixin and is efficient in accelerating the wound healing as well as in reducing the scar tissue area compared with pure PCL nanofibers. Therefore, soft material Bixin-loaded PCL nanofibers are a promising candidate for use in wound dressing.
local.identifier.orcidhttps://orcid.org/0000-0002-8876-4907
local.identifier.orcidhttps://orcid.org/0000-0001-9066-414X
local.identifier.orcidhttps://orcid.org/0000-0002-0560-8491
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33724

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