Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study

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dc.creatorHugo José Alves
dc.creatorWalyson Coelho Costa
dc.creatorJaqueline Silva de Oliveira
dc.creatorEva Lídia Arcoverde Medeiros
dc.creatorCarolina Senra Alves de Souza
dc.creatorJuliana Wilke Saliba
dc.creatorAndré Luiz Menezes
dc.creatorEneida Santos de Oliveira
dc.creatorTalita Emile Ribeiro Adelino
dc.creatorNatalia Rocha Guimaraes
dc.creatorAdriana Aparecida Ribeiro
dc.creatorJoão Locke Ferreira de Araújo
dc.creatorRennan Garcias Moreira
dc.creatorDanielle Alves Gomes Zauli
dc.creatorJoice do Prado Silva
dc.creatorFrederico Scott Varella Malta
dc.creatorAlessandro Clayton de Souza Ferreira
dc.creatorAna Valesca Fernandes Gilson Silva
dc.creatorPoliane Alfenas-zerbini
dc.creatorFlavia Oliveira de Souza
dc.creatorAdriano de Paula Sabino
dc.creatorLaura do Amaral Xavier
dc.creatorPaula Luize Camargos Fonseca
dc.creatorNatália Virtude Carobin
dc.creatorAlex Fiorini de Carvalho
dc.creatorKarine Lima Lourenço
dc.creatorSantuza Maria Ribeiro Teixeira
dc.creatorAna Paula Salles Moura Fernandes
dc.creatorFlavio Guimarães da Fonseca
dc.creatorJônatas Santos Abrahão
dc.creatorFelipe Campos de Melo Iani
dc.creatorRodrigo Araújo Lima Rodrigues
dc.creatorRenan Pedra de Souza
dc.creatorFilipe Romero Rebello Moreira
dc.creatorRenato Santana Aguiar
dc.creatorDiego Menezes Bonfim
dc.creatorDaniel Costa Queiroz
dc.creatorLucyene Miguita
dc.creatorRafael Marques de Souza
dc.creatorVictor Emmanuel Viana Geddes
dc.date.accessioned2023-12-01T21:08:56Z
dc.date.accessioned2025-09-09T00:36:23Z
dc.date.available2023-12-01T21:08:56Z
dc.date.issued2022-12-09
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetos
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/v14122747
dc.identifier.issn1999-4915
dc.identifier.urihttps://hdl.handle.net/1843/61649
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofViruses
dc.rightsAcesso Aberto
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectGenomas
dc.subject.otherPhylodinamics
dc.subject.otherPCR-genotyping
dc.subject.otherSARS-CoV-2 spread
dc.subject.otherGenome sequencing
dc.subject.otherVariants
dc.titleMonitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study
dc.typeArtigo de periódico
local.citation.epage15
local.citation.issue12
local.citation.spage2747
local.citation.volume14
local.description.resumoSince its first identification in Brazil, the variant of concern (VOC) Gamma has been associated with increased infection and transmission rates, hospitalizations, and deaths. Minas Gerais (MG), the second-largest populated Brazilian state with more than 20 million inhabitants, observed a peak of cases and deaths in March–April 2021. We conducted a surveillance study in 1240 COVID-19-positive samples from 305 municipalities distributed across MG’s 28 Regional Health Units (RHU) between 1 March to 27 April 2021. The most common variant was the VOC Gamma (71.2%), followed by the variant of interest (VOI) zeta (12.4%) and VOC alpha (9.6%). Although the predominance of Gamma was found in most of the RHUs, clusters of Zeta and Alpha variants were observed. One Alpha-clustered RHU has a history of high human mobility from countries with Alpha predominance. Other less frequent lineages, such as P.4, P.5, and P.7, were also identified. With our genomic characterization approach, we estimated the introduction of Gamma on 7 January 2021, at RHU Belo Horizonte. Differences in mortality between the Zeta, Gamma and Alpha variants were not observed. We reinforce the importance of vaccination programs to prevent severe cases and deaths during transmission peaks.
local.identifier.orcidhttps://orcid.org/0000-0001-9469-9673
local.identifier.orcidhttps://orcid.org/0000-0002-8103-9235
local.identifier.orcidhttps://orcid.org/0000-0002-9603-455X
local.identifier.orcidhttps://orcid.org/0000-0002-6607-8818
local.identifier.orcidhttps://orcid.org/0000-0001-6863-7970
local.identifier.orcidhttps://orcid.org/0000-0002-4178-0387
local.identifier.orcidhttps://orcid.org/0000-0002-0358-6161
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE FARMÁCIA SOCIAL
local.publisher.departmentFARMACIA - FACULDADE DE FARMACIA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/1999-4915/14/12/2747

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