Severe pediatric asthma refractory to treatment: the ongoing challenge of exacerbation

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dc.creatorMônica Versiani Nunes Pinheiro de Queiroz
dc.creatorJoana Versiani Chiabi de Queiroz
dc.creatorLaura Maria de Lima Belizário Facury Lasmar
dc.date.accessioned2024-06-12T20:56:19Z
dc.date.accessioned2025-09-09T00:08:33Z
dc.date.available2024-06-12T20:56:19Z
dc.date.issued2017
dc.identifier.issn2333-6625
dc.identifier.urihttps://hdl.handle.net/1843/69178
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical Research in Pulmonology
dc.rightsAcesso Aberto
dc.subjectAsma
dc.subjectCriança
dc.subjectAdolescente
dc.subjectValor preditivo dos testes
dc.subjectProgressão da doença
dc.subject.otherSevere refractory asthma
dc.subject.otherChildren and adolescents
dc.subject.otherPredictive factors
dc.subject.otherExacerbation
dc.titleSevere pediatric asthma refractory to treatment: the ongoing challenge of exacerbation
dc.typeArtigo de periódico
local.citation.issue1
local.citation.volume5
local.description.resumoThe objective of this study was to review the last 16 years of literature on the clinical and functional risk factors for asthma exacerbation, as well as on biochemical parameters in severe pediatric asthma refractory to treatment (SPART). In searches of the Cochrane/Brazilian Virtual Library of Health, Latin American and Caribbean Health Sciences Literature, Medline, Brazilian Office for the Advancement of Higher Education, and PubMed databases, we employed the following search terms/strings: “severe asthma” or “refractory asthma” or “problematic asthma” or “difficult-to-treat asthma”; “exacerbation”; “risk factors” or “predictors”; and “pediatric” or “children and adolescents”. We limited our searches to articles published between 1999 and 2016. We selected 26 original or review articles on severe pediatric asthma that addressed age, recent severe exacerbations, the level of asthma control, regular follow-up, comorbidities, behavioral factors, viral infection, and passive smoking, biomarkers of inflammation, serum vitamin D levels, and pulmonary function. However, we found very few studies dealing with SPART. Severe asthma is a heterogeneous, dynamic disease in which the various predictors of exacerbation described assess different aspects of the disease and are complementary. Such factors should be analyzed from a multifactorial and individualized perspective, because many of them are potentially modifiable.
local.identifier.orcidhttps://orcid.org/0000-0003-3183-0990
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://www.jscimedcentral.com/jounal-article-info/Clinical-Research-in-Pulmonology/Severe-Pediatric-Asthma--Refractory-to-Treatment%3A--The-Ongoing-Challenge-of--Exacerbation-2398#

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