Immunoexpression of autophagy-related proteins in salivary gland tumors: an exploratory study

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dc.creatorEmanuene Galdino Pires
dc.creatorChristany Rodrigues Ferreira
dc.creatorRoberta Barroso Cavalcante
dc.creatorMaria Cassia Ferreira de Aguiar
dc.creatorRicardo Alves de Mesquita
dc.creatorPollianna Muniz Alves
dc.creatorCassiano Francisco Weege Nonaka
dc.date.accessioned2024-08-26T21:19:43Z
dc.date.accessioned2025-09-08T22:59:28Z
dc.date.available2024-08-26T21:19:43Z
dc.date.issued2023-04-28
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s12105-023-01556-8
dc.identifier.issn1936-0568
dc.identifier.urihttps://hdl.handle.net/1843/75082
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHead and Neck Pathology
dc.rightsAcesso Restrito
dc.subjectAutophagy-related proteins
dc.subjectAutophagy
dc.subjectImmunohistochemistry
dc.subjectSirolimus
dc.subjectAdenoma, pleomorphic
dc.subjectCarcinoma, mucoepidermoid
dc.subjectCarcinoma, adenoid cystic
dc.subject.othersalivary gland neoplasms
dc.subject.otherimmunohistochemistry
dc.titleImmunoexpression of autophagy-related proteins in salivary gland tumors: an exploratory study
dc.typeArtigo de periódico
local.citation.epage598
local.citation.issue3
local.citation.spage589
local.citation.volume17 Head and neck pathology assunto Autophagy
local.description.resumoBackground: Autophagy is a cellular survival mechanism involved in several human diseases, but its participation in the development of salivary gland tumors is not fully understood. This study investigated the immunoexpression of autophagy-related proteins (autophagy-related 7 [Atg7], microtubule-associated protein 1 light chain 3A [LC3A], microtubule-associated protein 1 light chain 3B [LC3B], protein p62 [p62], and phosphorylated mammalian target of rapamycin [p-mTOR]) in pleomorphic adenoma (PA), polymorphous adenocarcinoma (PAC), mucoepidermoid carcinoma (MEC), and adenoid cystic carcinoma (ACC) of salivary glands. Methods: Twenty PAs, 20 PACs, 20 MECs, and 14 ACCs were selected. The percentages of cytoplasmic and nuclear positivity for autophagy-related proteins in neoplastic cells were assessed and correlated with histopathological parameters. Results: Cytoplasmic immunoexpression of Atg7 was observed in all groups, with high median percentages of positivity. Regarding LC3A and LC3B, cytoplasmic immunoexpression was found in most PACs (95%) and in all cases of PA, MEC and ACC, with the highest percentages of positivity in PACs and PAs (p < 0.005). ACCs exhibited lower cytoplasmic immunoexpression of p-mTOR (p < 0.005) and lower nuclear expression of p62 (p < 0.05) when compared to PAs, PACs and MECs. Low nuclear immunoexpression of Atg7, LC3A and p-mTOR and absence of nuclear staining for LC3B were observed in all groups. Regarding histopathological parameters of PAs, MECs and ACCs, there were no significant differences in the expression of autophagy-related proteins. In all groups, positive correlations were observed between the immunoexpression of some autophagy-related proteins (p < 0.05). Conclusions: The results suggest the participation of autophagy in the pathogenesis of PA, PAC, MEC, and ACC of salivary glands. Upregulation of autophagy and reduced nuclear translocation of p62 may contribute to the aggressive biological behavior of salivary gland ACC.
local.identifier.orcidhttps://orcid.org/0000-0001-9273-376X
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12105-023-01556-8

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