Inulin prebiotic dietary supplementation improves metabolic parameters by reducing the Toll-like receptor 4 transmembrane protein gene and interleukin 6 expression in adipose tissue

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dc.creatorCarla Dayana Durães Abreu
dc.creatorBruna Viana Caldas
dc.creatorGuilherme Henrique Mendes Ribeiro
dc.creatorCharles Martins Aguilar
dc.creatorLucyana Conceição Farias
dc.creatorAndré Luiz Sena Guimarães
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorMaria Beatriz Abreu Glória
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2023-11-07T10:15:44Z
dc.date.accessioned2025-09-08T22:51:29Z
dc.date.available2023-11-07T10:15:44Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.phanu.2022.100316
dc.identifier.issn2213-4344
dc.identifier.urihttps://hdl.handle.net/1843/60548
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Restrito
dc.subjectPrebióticos
dc.subjectNutrição
dc.subjectTecido adiposo
dc.subjectInflamação
dc.subjectSíndrome metabólica
dc.titleInulin prebiotic dietary supplementation improves metabolic parameters by reducing the Toll-like receptor 4 transmembrane protein gene and interleukin 6 expression in adipose tissue
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume22
local.description.resumoBackground: Lifestyle modifications have increased the consumption of ultra-processed foods, fat, sugar, and salt worldwide and also decreased dietary fiber due to reduced legume, grain, and vegetable intake. Ultimately, the contemporary food intake profile has increased the incidence of obesity and chronic inflammatory diseases. Probiotic dietary supplementation is a viable health option. Methods: Male Swiss mice were fed with two diets for four weeks: standard and standard +Inulin. The serum biochemistry data, histology, and inflammatory-related genes’ mRNA expression in adipose tissue were analyzed. Results: The primary results showed that inulin dietary supplementation decreased the Toll-like receptor 4 transmembrane protein gene (TLR4) expression and interleukin 6 (IL6) in the epididymal adipose tissue, resulting in decreased adipocyte hypertrophy. The high-density lipoprotein (HDL) was increased and TGP enzymes (related to liver injury risk) were decreased also improving insulin sensitivity. Conclusion: The present study revealed that inulin supplementation could improve the onset of chronic inflammation-related markers in adipose tissue indicating that inulin is a natural anti-inflammatory alternative. Data Availability Statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2213434422000299

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