Dietary supplementation with Madagascar cockroach (Gromphadorhina portentosa) flour improves metabolic parameters reducing hepatic inflammatory markers in obese mice

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dc.creatorJanaina Ribeiro Oliveira
dc.creatorSérgio Henrique Sousa Santos
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorDeborah Farias Lelis
dc.creatorAlanna Fernandes Paraiso
dc.creatorAlfredo Mauricio Batista de Paula
dc.creatorAndre Luiz Sena Guimarães
dc.creatorJuliana Pinto de Lima
dc.creatorJunio Cota Silva
dc.creatorDiego Vicente Costa
dc.date.accessioned2023-12-08T17:45:45Z
dc.date.accessioned2025-09-09T00:01:05Z
dc.date.available2023-12-08T17:45:45Z
dc.date.issued2023
dc.identifier.issn2352-4588
dc.identifier.urihttps://hdl.handle.net/1843/61864
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Insects as Food and Feed
dc.rightsAcesso Restrito
dc.subjectInsetos comestíveis
dc.subjectFigado - Insuficiência
dc.subjectObesidade
dc.subject.otherInsect
dc.subject.otherBug protein
dc.subject.otherFat
dc.subject.otherHepatic diseases
dc.subject.otherInflammation
dc.subject.otherSteatosis
dc.titleDietary supplementation with Madagascar cockroach (Gromphadorhina portentosa) flour improves metabolic parameters reducing hepatic inflammatory markers in obese mice
dc.typeArtigo de periódico
local.citation.issue2
local.citation.volume9
local.description.resumoThe edible insect dietary supplementation option for nutritional disturbances is a promising scientific investigation field, especially in the obesity context. The aim of the present study was to evaluated the Madagascar cockroach (Gromphadorhina portentosa) flour (CF) influence on the body composition, biochemical profile and inflammatory markers in obese mice liver. Mice were divided in four groups: Control AIN-93, AIN-93+Madagascar cockroach flour (AIN93+CF), high-fat diet (HFD) and HFD+Madagascar cockroach flour (HFD+CF). The groups were treated for eight weeks (4 weeks of obesity induction + 4 weeks supplemented with CF isocaloric diet). Body composition, biochemical levels and molecular markers were evaluated. The main results showed a decreased fasting glucose, total cholesterol, triglycerides, and pyruvic transaminase/aspartate aminotransferase in the HFD-CF treated animals compared to HFD. Moreover, it was observed a decreased liver interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α) inflammatory markers expression in HFD+CF mice. These data reveal that Madagascar cockroach flour may be a useful dietary supplement to improve biochemical and inflammatory obesity alterations.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.3920/JIFF2022.0043

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