Experimental furcal perforation treated with mineral trioxide aggregate plus selenium: immune response

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dc.creatorMarcela Carvalho Espaladori
dc.creatorKamilla Faria Maciel
dc.creatorLuciana Carla Neves de Brito
dc.creatorToshihisa Kawai
dc.creatorLeda Quercia Vieira
dc.creatorAntônio Paulino Ribeiro Sobrinho
dc.date.accessioned2022-09-24T16:53:14Z
dc.date.accessioned2025-09-08T23:09:04Z
dc.date.available2022-09-24T16:53:14Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.issn18073107
dc.identifier.urihttps://hdl.handle.net/1843/45441
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Oral Research
dc.rightsAcesso Aberto
dc.subjectCytokines
dc.subjectSelenium
dc.subjectImmunophenotyping
dc.subjectAnimals
dc.subject.otherSelenium
dc.subject.otherCytokines
dc.subject.otherImmunophenotyping
dc.subject.otherModels
dc.subject.otherAnimal
dc.titleExperimental furcal perforation treated with mineral trioxide aggregate plus selenium: immune response
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume32
local.description.resumoThe aim of this study is to evaluate the expression of cytokines in response to mineral trioxide aggregate (MTA) plus selenium in germ-free mice with experimental furcal perforation. The first left maxillary molar was opened, and the furcal area was perforated and treated with post-MTA-Se (experimental group). The same surgical intervention was performed for the maxillary right first molar, which was treated with MTA (control group). Fifteen mice were sacrificed 7, 14, and 21 days after furcal perforation, and periapical tissue samples were collected. The mRNA expression levels of the cytokines TGF-β, TNF-α, IFN-γ, HPRT, IL-10, IL-4, RANK, RANKL, IL-1, and IL-17 were assessed by using real-time polymerase chain reaction. In the experimental group, at 21-days post-MTA-Se sealing, the mRNA levels of TNF-α and IL-10 were upregulated compared with those in the control group (p < 0.05). Futher assessment revealed basal mRNA expression levels of IL-1α, IFN-γ, RANK, RANKL, IL-17A, IL-4, and TGF-β, over long experimental times, in both the experimental and control groups (p > 0.05). In conclusion, MTA+Se sealing favoured increased expression of IL-10 and TNF-α at later time points (day 21).
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bor/a/zQS8nNbJFnMrjmhmQPWRFnn/abstract/?lang=en

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