Alpha-tocopheryl succinate and doxorubicin-loaded liposomes improve drug uptake and tumor accumulation in a murine breast tumor model

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dc.creatorFernanda Boratto
dc.creatorEduardo Lages
dc.creatorCristina Loures
dc.creatorAdriano Sabino
dc.creatorAngelo Malachias
dc.creatorDanyelle Townsend
dc.creatorAndré Luís Branco de Barros
dc.creatorLucas Antonio Miranda Ferreira
dc.creatorElaine Amaral Leite
dc.date.accessioned2025-02-04T16:40:38Z
dc.date.accessioned2025-09-09T00:32:09Z
dc.date.available2025-02-04T16:40:38Z
dc.date.issued2023-06-23
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2023.115034
dc.identifier.issn0753-3322
dc.identifier.urihttps://hdl.handle.net/1843/79648
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.rightsAcesso Aberto
dc.subjectCâncer
dc.subjectTumores
dc.subjectBiologia celular e molecular
dc.subject.otherDoxorubicin
dc.subject.otherAlpha-tocopheryl succinate
dc.subject.otherPH-sensitive liposomes
dc.subject.otherTumor accumulation
dc.subject.otherBreast cancer
dc.titleAlpha-tocopheryl succinate and doxorubicin-loaded liposomes improve drug uptake and tumor accumulation in a murine breast tumor model
dc.typeArtigo de periódico
local.citation.epage08
local.citation.spage01
local.citation.volume165
local.description.resumoLiposomes composed of a rigid bilayer have high plasma stability; however, they can be challenged in efficacy due to complications in releasing the encapsulated drug as well as being internalized by the tumor cell. On the other hand, fusogenic liposomes may fuse with the plasmatic membrane and release encapsulated material directly into the cytoplasm. In a previous study, fusogenic liposomes composed of alpha-tocopheryl succinate (TS) and doxorubicin (DOX) were developed (pHSL-TS-DOX). These stabilized tumor growth and reduced toxicity compared to a commercial formulation. In the present study, we investigated whether cellular uptake or DOX accumulation in the tumor could justify the better performance of the pHSL-TS-DOX formulation. Release, deformability, and DOX plasmatic concentration studies were also carried out. pHSL-TS-DOX showed an adequate release profile and demonstrated characteristics of a deformable formulation. Data from apoptosis, cell cycle, and nuclear morphology studies have shown that the induction of cell death caused by pHSL-TS-DOX occurred more quickly. Higher DOX cellular uptake and tumor accumulation were observed when pHSL-TSDOX was administered, demonstrating better drug delivery capacity. Therefore, better DOX uptake as well as tumor accumulation explain the great antitumor activity previously demonstrated for this formulation.
local.identifier.orcidhttps://orcid.org/0000-0001-6704-4057
local.identifier.orcidhttps://orcid.org/0000-0002-2912-5312
local.identifier.orcidhttps://orcid.org/0000-0001-8562-8689
local.identifier.orcidhttps://orcid.org/0000-0002-8703-4283
local.identifier.orcidhttps://orcid.org/0000-0001-7979-1156
local.identifier.orcidhttps://orcid.org/0000-0003-4782-5416
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0753332223008247

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