The link between exercise and homocysteine in the Alzheimer’s disease: a bioinformatic network model

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dc.creatorLuana Lemos Leão
dc.creatorLaís Francielle Francisca Felício
dc.creatorKnut Engedal
dc.creatorGro Gujord Tangen
dc.creatorKari Midtbø Kristiansen
dc.creatorSérgio Henrique Sousa Santos
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorRenato Sobral Monteiro Júnior
dc.date.accessioned2023-05-04T11:29:57Z
dc.date.accessioned2025-09-09T00:58:12Z
dc.date.available2023-05-04T11:29:57Z
dc.date.issued2021-07-06
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.2174/1871527320666210706122618
dc.identifier.issn1996-3181
dc.identifier.urihttps://hdl.handle.net/1843/52789
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCNS & Neurological Disorders - Drug Targets
dc.rightsAcesso Restrito
dc.subjectAlzheimer, Doença de
dc.subjectHomocisteína
dc.subjectBioinformática
dc.subjectEstresse oxidativo
dc.subjectÓxido nítrico
dc.titleThe link between exercise and homocysteine in the Alzheimer’s disease: a bioinformatic network model
dc.typeArtigo de periódico
local.citation.epage821
local.citation.issue9
local.citation.spage814
local.citation.volume20
local.description.resumoElevated peripheral expression of homocysteine (Hcy) is associated with an increased risk of coronary heart disease and stroke, diabetes, and cancer. It is also associated with cognitive impairment as it has been reported that high levels of Hcy cause cognitive dysfunction and memory deficit. Among several etiological factors that contribute to the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), Hcy seems to directly contribute to the generation of neurotoxicity factors. This study aims to hypothesize the molecular mechanism by which exercise can reduce the risk of neurological complications promoted by hyperhomocysteinemia (HHcy), and discuss how exercise could reduce the risk of developing AD by using bioinformatics network models. According to the genes network, there are connections between proteins and amino acids associated with Hcy, exercise, and AD. Studies have evidenced that exercise may be one of several processes by which acid nitric availability can be maximized in the human body, which is particularly important in reducing cell loss and tau pathology and, thereby, leading to a reduced risk of complications associated with HHcy and AD.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.eurekaselect.com/article/116485

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