Oral mucositis: current knowledge and future directions

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dc.creatorSameep S.Shetty
dc.creatorMeghana Maruthi
dc.creatorVasantha Dhara
dc.creatorJosé Alcides Almeida de Arruda
dc.creatorLucas Guimarães Abreu
dc.creatorRicardo Alves de Mesquita
dc.creatorAntonio Lucio Teixeira
dc.creatorTarcília Aparecida da Silva
dc.creatorYash Merchant
dc.date.accessioned2025-04-30T18:57:48Z
dc.date.accessioned2025-09-08T22:49:50Z
dc.date.available2025-04-30T18:57:48Z
dc.date.issued2022-05
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.disamonth.2021.101300
dc.identifier.issn1557-8194
dc.identifier.urihttps://hdl.handle.net/1843/81991
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofDisease-a-Month
dc.rightsAcesso Restrito
dc.subjectAntineoplastic agents
dc.subjectDiagnosis, differential
dc.subjectStomatitis
dc.subjectSalivary glands
dc.subjectClinical study
dc.subject.otherChemotherapy
dc.subject.otherDifferential diagnosis
dc.subject.otherHead and neck cancer radiation
dc.subject.otherManagement
dc.subject.otherOral mucositis
dc.subject.otherOral oncology
dc.subject.otherSalivary glands
dc.titleOral mucositis: current knowledge and future directions
dc.typeArtigo de periódico
local.citation.issue5
local.citation.spage101300
local.citation.volume68
local.description.resumoOral mucositis secondary to head and neck chemoradiation displays a complex molecular pathogenesis involving epithelial and microvascular injury, release of pro-inflammatory cytokines, and host-microbiome communications. These processes lead to oxidative stress and the release of reactive oxygen species that stifle the structural integrity of the oral mucosa, with emergence of erosions and ulcers. The consequences are malnutrition, psychological/psychiatric symptoms, poor quality of life, and occurrence of opportunistic infections. The latter pose a major challenge due to the risk of interruption of anti-neoplastic therapy, tumour recurrence and, ultimately, death. This article aims to present the clinical characteristics, molecular pathogenesis, and an overview of the predisposing factors and current management of oral mucositis. It is anticipated that the future direction of the management of oral mucositis will focus on evidence-based prehabilitation and pre- and per-chemoradiation therapy monitoring.
local.identifier.orcidhttps://orcid.org/0000-0001-8729-9348
local.identifier.orcidhttps://orcid.org/0000-0002-3805-873X
local.identifier.orcidhttps://orcid.org/0000-0003-4312-8322
local.identifier.orcidhttps://orcid.org/0000-0002-6599-3950
local.identifier.orcidhttps://orcid.org/0000-0003-2258-8071
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.identifier.orcidhttps://orcid.org/0000-0002-9621-5422
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-3871-897X
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0011502921001760?via%3Dihub

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