Online measurement of viscosity for biological systems in stirred tank bioreactors

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dc.creatorMaximilian Schelden
dc.creatorWilliam James Nogueira Lima
dc.creatorEric Will Doerr
dc.creatorMartin Wunderlich
dc.creatorLars Rehmann
dc.creatorJochen Büchs
dc.creatorLars Regestein
dc.date.accessioned2022-09-20T18:48:38Z
dc.date.accessioned2025-09-09T01:18:51Z
dc.date.available2022-09-20T18:48:38Z
dc.date.issued2016-11-14
dc.identifier.doihttps://doi.org/10.1002/bit.26219
dc.identifier.issn1097-0290
dc.identifier.urihttps://hdl.handle.net/1843/45331
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBiotechnology and Bioengineering
dc.rightsAcesso Restrito
dc.subjectBiorreatores
dc.subjectViscosidade
dc.subjectBiopolímeros
dc.subjectXanthomonas campestris
dc.subjectSistemas biológicos
dc.subject.otherOnline measurement
dc.subject.otherviscosity
dc.subject.otherstirred tank bioreactors
dc.titleOnline measurement of viscosity for biological systems in stirred tank bioreactors
dc.typeArtigo de periódico
local.citation.epage997
local.citation.issue5
local.citation.spage990
local.citation.volume114
local.description.resumoOne of the most critical parameters in chemical and biochemical processes is the viscosity of the medium. Its impact on mixing, as well as on mass and energy transfer is substantial. An increase of viscosity with reaction time can be caused by the formation of biopolymers like xanthan or by filamentous growth of microorganisms. In either case the properties of fermentation broth are changing and frequently non-Newtonian behavior are observed, resulting in major challenges for the measurement and control of mixing and mass transfer. This study demonstrates a method for the online determination of the viscosity inside a stirred tank reactor. The presented method is based on online measurement of heat transfer capacity from the bulk medium to the jacket of the reactor. To prove the feasibility of the method, fermentations with the xanthan producing bacterium Xanthomonas campestris pv. campestris B100 as model system were performed. Excellent correlation between offline measured apparent viscosity and online determined heat transfer capacity were found. The developed tool should be applicable to any other process with formation of biopolymers and filamentous growth.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/bit.26219

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