Virgin coconut oil is effective to treat metabolic and inflammatory dysfunction induced by high refined carbohydrate-containing diet in mice

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dc.creatorMarina Campos Zicker
dc.creatorAna Letícia Malheiros Silveira
dc.creatorDébora Romualdo Lacerda
dc.creatorDébora Fernandes Rodrigues
dc.creatorCíntia Tarabal Oliveira
dc.creatorLetícia Maria de Souza Cordeiro
dc.creatorLeandro Ceotto Freitas Lima
dc.creatorSergio Henrique Sousa Santos
dc.creatorMauro Martins Teixeira
dc.creatorAdaliene Versiani Matos Ferreira
dc.date.accessioned2022-08-29T14:49:46Z
dc.date.accessioned2025-09-08T23:00:05Z
dc.date.available2022-08-29T14:49:46Z
dc.date.issued2019-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.jnutbio.2018.08.013
dc.identifier.issn1873-4847
dc.identifier.urihttps://hdl.handle.net/1843/44657
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofThe Journal of Nutritional Biochemistry
dc.rightsAcesso Restrito
dc.subjectObesidade
dc.subjectTriglicerídeos
dc.subjectInflamação
dc.subjectÓleo de coco
dc.subjectAlimentos funcionais
dc.titleVirgin coconut oil is effective to treat metabolic and inflammatory dysfunction induced by high refined carbohydrate-containing diet in mice
dc.typeArtigo de periódico
local.citation.epage128
local.citation.spage117
local.citation.volume63
local.description.resumoThe global rise in obesity rates is alarming since this condition is associated with chronic low-grade inflammation and secondary comorbidities as glucose intolerance, cardiovascular disease and liver damage. Therefore, a lot of dietary approaches are proposed to prevent and to treat obesity and its associated disorders. Virgin coconut oil (VCO) is well known as a functional food due to its significant amounts of medium-chain triglycerides. This study aimed to evaluate the effect of VCO on adiposity, metabolic and inflammatory dysfunctions induced by a high-refined carbohydrate-containing (HC) diet in mice. Male BALB/c mice were divided into two groups and fed with control (C) or HC diet to induce obesity for eight weeks. At the 9th week mice fed with HC diet were randomly regrouped into four groups, and were kept this way until the 12th week, as following: (i) HC diet alone or HC diet supplemented with three different VCO doses (ii) 1000 mg/kg, (iii) 3000 mg/kg and (iv) 9000 mg/kg. Regardless of the concentration used, VCO supplementation promoted lower adiposity and also improvement in glucose tolerance, lower serum glucose and lipid levels and decreased hepatic steatosis. Moreover, VCO intake induced a lower inflammatory response due to decreased number of leukocytes and TNF-α and IL-6 concentrations in adipose tissue, as well as reduced counts of total leukocytes, mononuclear and polymorphonuclear circulating cells. Our data showed that VCO can be considered as an interesting potential dietary approach to attenuate obesity and its metabolic and inflammatory alterations.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0955286318300986

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