Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes

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dc.creatorÁtila Duque Rossi
dc.creatorRenato Santana de Aguiar
dc.creatorLuiza Mendonça Higa
dc.creatorAlice Laschuk Herlinger
dc.creatorMarcelo Ribeiro Alves
dc.creatorMariane Talon de Menezes
dc.creatorAna Lucia Moraes Giannini
dc.creatorCynthia Chester Cardoso
dc.creatorAndrea da Poian
dc.creatorAmilcar Tanuri
dc.date.accessioned2023-07-17T20:12:38Z
dc.date.accessioned2025-09-08T23:35:59Z
dc.date.available2023-07-17T20:12:38Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.3389/fcimb.2021.714088
dc.identifier.issn2235-2988
dc.identifier.urihttps://hdl.handle.net/1843/56493
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Cellular and Infection Microbiology
dc.rightsAcesso Aberto
dc.subjectDengue - Epidemiologia
dc.subjectRelação hospedeiro-virus
dc.subjectMonocitos
dc.subjectGenetica - Expressão
dc.subject.otherMicroRNA
dc.subject.otherMonocyte
dc.subject.otherDengue
dc.subject.otherGene expression
dc.subject.otherVirus-host
dc.titleDifferential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume11
local.description.resumoDengue virus (DENV) is the most widespread arbovirus, responsible for a wide range of clinical manifestations, varying from self-limited illness to severe hemorrhagic fever. Dengue severity is associated with host intense proinflammatory response and monocytes have been considered one of the key cell types involved in the early steps of DENV infection and immunopathogenesis. To better understand cellular mechanisms involved in monocyte infection by DENV, we analyzed the expression levels of 754 human microRNAs in DENV-infected THP-1 cells, a human monocytic cell line. Eleven human microRNAs showed differential expression after DENV infection and gene ontology and enrichment analysis revealed biological processes potentially affected by these molecules. Five downregulated microRNAs were significantly linked to cellular response to stress, four to cell death/apoptosis, two to innate immune responses and one upregulated to vesicle mediated, TGF-β signaling, phosphatidylinositol mediated signaling, lipid metabolism process and blood coagulation.
local.identifier.orcidhttps://orcid.org/0000-0001-6235-8807
local.identifier.orcidhttps://orcid.org/0000-0001-5180-3717
local.identifier.orcidhttps://orcid.org/0000-0003-2622-534X
local.identifier.orcidhttps://orcid.org/0000-0002-7660-7058
local.identifier.orcidhttps://orcid.org/0000-0002-8663-3364
local.identifier.orcidhttps://orcid.org/0000-0002-3969-704X
local.identifier.orcidhttps://orcid.org/0000-0003-0570-750X
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fcimb.2021.714088/full

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