The time-course of thermoregulatory responses during treadmill running is associated with running duration-dependent hypothalamic neuronal activation in rats

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dc.creatorPaulo Marcelo de Andrade Lima
dc.creatorHelton Oliveria Campos
dc.creatorDaniela Rocha da Costa Fóscolo
dc.creatorRaphael Escorsim Szawka
dc.creatorSamuel Penna Wanner
dc.creatorCândido Celso Coimbra
dc.date.accessioned2022-08-01T17:18:05Z
dc.date.accessioned2025-09-09T00:20:25Z
dc.date.available2022-08-01T17:18:05Z
dc.date.issued2019-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1007/s00429-019-01933-6
dc.identifier.issn1863-2661
dc.identifier.urihttps://hdl.handle.net/1843/43852
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrain Structure and Function
dc.rightsAcesso Restrito
dc.subjectFadiga
dc.subjectCorpo - Temperatura - Regulação
dc.subjectHipotálamo
dc.subjectExercício Físico
dc.subject.otherFatigue
dc.subject.otherHeat
dc.subject.otherHypothalamus
dc.subject.otherPhysical exercise
dc.subject.otherTemperature
dc.subject.otherc-Fos
dc.titleThe time-course of thermoregulatory responses during treadmill running is associated with running duration-dependent hypothalamic neuronal activation in rats
dc.typeArtigo de periódico
local.citation.epage2786
local.citation.issue8
local.citation.spage2775
local.citation.volume224
local.description.resumoThis study evaluated the hypothalamic neuronal activation during exercise and investigated whether this activation is related to heat storage and exercise duration. Rats were subjected to a treadmill running that was interrupted at three different moments: (1) at the early phase, when minimal heat dissipation occurred due to tail vasoconstriction and the tail skin temperature (Tskin) reached its nadir; (2) at the steady-state phase, when both the Tskin and core body temperature (Tcore) plateaued at a high level (~ 20 min); and (3) at fatigue, when Tcore and Tskin were still elevated. c-Fos expression in the medial and ventromedial preoptic areas (mPOA and vmPOA), median preoptic nucleus (MnPO), paraventricular and supraoptic nucleus (PVN and SON), and septohypothalamic nucleus (SHy) was determined. Exercise increased the expression of c-Fos in all brain areas, but with different activation patterns of activation. c-Fos expression in the SHy and vmPOA was similar in all exercising groups, while in the mPOA, MnPO, and PVN, c-Fos expression gradually increased during exercise. Increased c-Fos in the SON was only evident after 20 min of exercise. Neuronal activation in the mPOA, MnPO, PVN, and SON was positively correlated with both exercise duration and heat storage. Our findings indicate that with the exception of SON, the brain areas analyzed are recruited following small changes in Tcore (~ 0.5 °C), while the SON is recruited only when Tcore reaches higher values (greater than 1.0 °C increase). c-Fos expression in the PVN, mPOA, MnPO, and SON is also influenced by exercise duration, which does not occur in the SHy and vmPOA.
local.identifier.orcidhttp://orcid.org/0000-0001-5720-8054
local.identifier.orcidhttps://orcid.org/0000-0002-2639-3469
local.identifier.orcidhttp://orcid.org/0000-0002-4659-1032
local.identifier.orcidhttps://orcid.org/0000-0001-8981-6724
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s00429-019-01933-6

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