Immunohistochemical analysis of neutrophils, interleukin-17, matrix metalloproteinase-9, and neoformed vessels in oral squamous cell carcinoma

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dc.creatorRicardo Natã Fonseca Silva
dc.creatorLaís Bueno Dallarmi
dc.creatorAna Karoline Carvalho Araujo
dc.creatorRita de Cássia Gonçalves de Alencar
dc.creatorElismauro Francisco Mendonça
dc.creatorTarcília Aparecida da Silva
dc.creatorAline Carvalho Batista
dc.creatorNadia Lago Costa
dc.date.accessioned2025-04-07T19:48:47Z
dc.date.accessioned2025-09-09T00:08:12Z
dc.date.available2025-04-07T19:48:47Z
dc.date.issued2018-10
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.12762
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/81353
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectAngiogenesis
dc.subjectInflammation
dc.subjectInterleukin-17
dc.subjectNeutrophils
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectMatrix metalloproteinase 9
dc.subjectPrognosis
dc.subjectEndoglin
dc.subjectNeoplasm metastasis
dc.subject.otherAngiogenesis
dc.subject.otherInflammation
dc.subject.otherInterleukin-17
dc.subject.otherNeutrophils
dc.subject.otherOral squamous cell carcinoma
dc.titleImmunohistochemical analysis of neutrophils, interleukin-17, matrix metalloproteinase-9, and neoformed vessels in oral squamous cell carcinoma
dc.typeArtigo de periódico
local.citation.epage863
local.citation.issue9
local.citation.spage856
local.citation.volume47
local.description.resumoBackground: Tumor-associated neutrophils (TAN), matrix metalloproteinase-9 (MMP-9), interleukin-17 (IL-17), and angiogenesis have been proposed as prognostic biomarkers of malignant tumors. The purpose of this study was to investigate these inflammatory markers as prognostic factors for oral squamous cell carcinoma (OSCC). Methods: Specimens of OSCC (n = 30), healthy oral mucosa (negative control, n = 10), oral leukoplakia (n = 10), and apical granuloma with abscess (positive inflammatory controls, n = 10) were immunostained for CD66b (neutrophils), MMP-9, IL-17, and CD105 (neoformed microvessels). Semiquantitative (IL-17) and quantitative (CD66b, IL-17, MMP-9, and CD105) analyses were performed. Clinical information (TNM stage, metastasis, recurrence, and survival) and tumor histological grade were also obtained. Results: Positivity for TAN, MMP-9, IL-17, and CD105 was higher in OSCC than in the negative control (P < 0.05) and oral leukoplakia, but similar to the positive inflammatory control. Coincident high counts of inflammatory markers (CD66b, MMP-9, IL-17, and CD105) were associated with lymph node metastasis of OSCC. Associations between high numbers of neoformed microvessels and advanced clinical stage and a higher degree of malignancy were also demonstrated. Conclusions: Combined positivity for TAN, MMP-9, IL-17, and CD105 appears to be associated with the metastasis-prone phenotype of OSCC.
local.identifier.orcidhttps://orcid.org/0000-0003-3506-5405
local.identifier.orcidhttps://orcid.org/0000-0002-6751-3279
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-2117-5593
local.identifier.orcidhttps://orcid.org/0000-0002-3298-867X
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12762

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