Age-related metabolic pathways changes in dental follicles: a pilot study

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dc.creatorVictor Coutinho Bastos
dc.creatorLiséte Celina Lange
dc.creatorAdriana Nori de Macedo
dc.creatorGisele André Baptista Canuto
dc.creatorCarolina Cavaliéri Gomes
dc.creatorRicardo Santiago Gomez
dc.creatorJéssica Gardone Vitório
dc.creatorRoberta Rayra Martins-chaves
dc.creatorFlávia Leite-Lima
dc.creatorYuri Abner Rocha Lebron
dc.creatorVictor Rezende Moreira
dc.creatorFilipe Fideles Duarte-Andrade
dc.creatorThaís Dos Santos Fontes Pereira
dc.creatorLucilaine Valéria de Souza Santos
dc.date.accessioned2023-06-29T17:52:13Z
dc.date.accessioned2025-09-08T23:08:04Z
dc.date.available2023-06-29T17:52:13Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/froh.2021.677731
dc.identifier.issn2673-4842
dc.identifier.urihttps://hdl.handle.net/1843/55553
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Oral Health
dc.rightsAcesso Aberto
dc.subjectCélulas - Envelhecimento
dc.subjectDentes - Doenças
dc.subjectBiologia do desenvolvimento
dc.subjectBoca - Doenças - Diagnóstico
dc.subjectCromatografia líquida
dc.subjectEspectrometria de massa
dc.subject.otherAging
dc.subject.otherDental follicle
dc.subject.otherDental sac
dc.subject.otherDevelopmental biology
dc.subject.otherOral pathology
dc.subject.otherUntargeted metabolomics
dc.subject.otherLC-MS
dc.titleAge-related metabolic pathways changes in dental follicles: a pilot study
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume2
local.description.resumoAging is not a matter of choice; it is our fate. The “time-dependent functional decline that affects most living organisms” is coupled with several alterations in cellular processes, such as cell senescence, epigenetic alterations, genomic instability, stem cell exhaustion, among others. Age-related morphological changes in dental follicles have been investigated for decades, mainly motivated by the fact that cysts and tumors may arise in association with unerupted and/or impacted teeth. The more we understand the physiology of dental follicles, the more we are able to contextualize biological events that can be associated with the occurrence of odontogenic lesions, whose incidence increases with age. Thus, our objective was to assess age-related changes in metabolic pathways of dental follicles associated with unerupted/impacted mandibular third molars from young and adult individuals. For this purpose, a convenience sample of formalin-fixed paraffin-embedded (FFPE) dental follicles from young (<16 y.o., n = 13) and adult (>26 y.o., n = 7) individuals was selected. Samples were analyzed by high-performance liquid chromatography-mass spectrometry (HPLC-MS)-based untargeted metabolomics. Multivariate and univariate analyses were conducted, and the prediction of altered pathways was performed by mummichog and Gene Set Enrichment Analysis (GSEA) approaches. Dental follicles from young and older individuals showed differences in pathways related to C21-steroid hormone biosynthesis, bile acid biosynthesis, galactose metabolism, androgen and estrogen biosynthesis, starch and sucrose metabolism, and lipoate metabolism. We conclude that metabolic pathways differences related to aging were observed between dental follicles from young and adult individuals. Our findings support that similar to other human tissues, dental follicles associated with unerupted tooth show alterations at a metabolic level with aging, which can pave the way for further studies on oral pathology, oral biology, and physiology.
local.identifier.orcidhttps://orcid.org/0000-0002-4125-3755
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA SANITÁRIA E AMBIENTAL
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/froh.2021.677731/full

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