Influence of pain-relieving therapies on inflammation and the expression of proinflammatory neuropeptides after dental bleaching treatment

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dc.creatorLivia Maria Alves Valentim da Silva
dc.creatorLuciano Tavares Angelo Cintra
dc.creatorMarjorie Oliveira Gallinari
dc.creatorFrancine Benetti
dc.creatorVanessa Rahal
dc.creatorEdilson Ervolino
dc.creatorSibele Alcantara
dc.creatorAndré Luiz Fraga Briso
dc.date.accessioned2022-11-11T22:57:18Z
dc.date.accessioned2025-09-09T00:27:20Z
dc.date.available2022-11-11T22:57:18Z
dc.date.issued2020-02-28
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.5395/rde.2020.45.e20
dc.identifier.issn22347658
dc.identifier.urihttps://hdl.handle.net/1843/47208
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRestorative Dentistry & Endodontics
dc.rightsAcesso Aberto
dc.subjectTooth bleaching
dc.subjectHydrogen peroxide
dc.subjectIbuprofen
dc.subjectResearch
dc.subjectPain
dc.subjectReactive oxygen species
dc.subject.otherHydrogen peroxide
dc.subject.otherTooth bleaching
dc.subject.otherIbuprofen
dc.subject.otherLaboratory research
dc.subject.otherPain
dc.subject.otherReactive oxygen species
dc.titleInfluence of pain-relieving therapies on inflammation and the expression of proinflammatory neuropeptides after dental bleaching treatment
dc.typeArtigo de periódico
local.citation.epage14
local.citation.issue2
local.citation.spage1
local.citation.volume45
local.description.resumoObjectives To minimize the tooth sensitivity caused by in-office bleaching, many dentists use non-steroidal anti-inflammatory drugs and topical desensitizing gels containing potassium nitrate and sodium fluoride. This study aimed to evaluate the influence of these substances on inflammation and the expression of substance P and calcitonin gene-related peptide in pulp nerve fibers. Materials and Methods Seventy-two rats were divided into 6 groups as follows: GI, control; GII, only dental bleaching; GIII, only ibuprofen; GIV, ibuprofen administered 30 minutes before and after the bleaching treatment and every 12 hours until the analysis; GV, only topical application of a desensitizing agent; and GVI, topical application of a desensitizing agent before dental bleaching. Placebo gel was applied to the upper left jaw and the bleaching agent was applied to the upper right jaw in all groups. Subsequently, the groups were divided into 3 subgroups based on the time of analysis: 0, 24, and 48 hours after bleaching (n = 8). The rats were euthanized and the maxillae were processed and evaluated by histopathological and immunohistochemical analyses. The data were analyzed using the Kruskal-Wallis test, followed by the Dunn test (p < 0.05). Results In the bleaching groups, the inflammatory process and expression of neuropeptides decreased over time. The animals in which a desensitizing agent was applied showed better results within 24 hours. Conclusions The use of a desensitizing agent had positive effects on inflammation and pain-related neuropeptide expression, minimizing the painful effects of dental bleaching treatment
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239683/

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