Use of autogenous bone and beta-tricalcium phosphate in maxillary sinus lifting: histomorphometric study and immunohistochemical assessment of RUNX2 and VEGF

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dc.creatorPereira
dc.creatorGorla
dc.creatorFernanda Brasil Daura Jorge Boos Lima
dc.creatorRoberta Okamoto
dc.creatorGarcia Júnior
dc.creatorEduardo Hochuli-Vieira
dc.date.accessioned2024-06-11T19:08:14Z
dc.date.accessioned2025-09-09T00:48:38Z
dc.date.available2024-06-11T19:08:14Z
dc.date.issued2017-04
dc.identifier.doihttps://doi.org/10.1016/j.ijom.2017.01.002
dc.identifier.issn09015027
dc.identifier.urihttps://hdl.handle.net/1843/69133
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgery
dc.rightsAcesso Restrito
dc.subjectBone transplantation
dc.subjectImmunohistochemistry
dc.subjectMaxillary sinus
dc.subjectHistology
dc.subject.otherbone graft; immunohistochemistry; maxillary sinus.
dc.subject.otherbusca dia 02/02/2024 assunto Bone Transplantation fao clínica Use of autogenous bone and beta-tricalcium phosphate in maxillary sinus lifting: histomorphometric study and immunohistochemical assessment of runx2 and vegf
dc.titleUse of autogenous bone and beta-tricalcium phosphate in maxillary sinus lifting: histomorphometric study and immunohistochemical assessment of RUNX2 and VEGF
dc.typeArtigo de periódico
local.citation.epage510
local.citation.issue4
local.citation.spage503
local.citation.volume46
local.description.resumoThe aim of this study was to compare the use of beta-tricalcium phosphate (β-TCP) (chronOS) with autogenous bone grafts alone in maxillary sinus elevation surgery. The test samples were β-TCP alone, β-TCP mixed with autogenous bone grafts (1:1), and autogenous bone grafts alone. Twelve maxillary sinuses were grafted with β-TCP (group 1), nine with β-TCP+autogenous bone graft (group 2), and 12 with autogenous bone graft (group 3). After 6 months, biopsies were obtained concurrent to the placement of dental implants; these were subjected to histomorphometric analysis and immunohistochemical analysis for runt-related transcription factor 2 (RUNX2) and vascular endothelial growth factor (VEGF). The average bone formation in group 1 was 46.3±11.6% in the pristine bone region, 47.6±9.9% in the intermediate region, and 44.8±22.1% in the apical region; in group 2, values were 35.0±15.8%, 32.5±13.7%, and 32.8±16.0%, respectively; in group 3, values were 43.1±16.0%, 31.0±13.0%, and 46.1±16.3%, respectively. Immunostaining of samples in group 2 showed high cellular activity and immature bone; this differed from groups 1 and 3, in which mature bone was demonstrated. Thus, this study showed that β-TCP presents the same behaviour as autogenous bone graft, which makes it a good bone substitute.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S090150271730019X?via%3Dihub

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