Using an aluminum hydroxide–chitosan matrix increased the vaccine potential and immune response of mice against multi-drug-resistant Acinetobacter baumannii

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dc.creatorTúllio Teixeira Deusdará
dc.creatorMellanie Karoline do Carmo Félix
dc.creatorHélio de Sousa Brito
dc.creatorEdson Wagner Silva Cangussu
dc.creatorWellington de Souza Moura
dc.creatorBenedito Albuquerque
dc.creatorMarcos Gontijo da Silva
dc.creatorGil Rodrigues dos Santos
dc.creatorPaula Benevides de Morais
dc.creatorElizângela Farias da Silva
dc.creatorYury Oliveira Chaves
dc.creatorLuís André Morais Mariuba
dc.creatorPaulo Afonso Nogueira
dc.creatorSpartaco Astolfi-Filho
dc.creatorEnedina Nogueira de Assunção
dc.creatorSabrina Epiphanio
dc.creatorClaudio Romero Farias Marinho
dc.creatorIgor Viana Brandi
dc.creatorKelvinson Fernandes Viana
dc.creatorEugênio Eduardo de Oliveira
dc.creatorAlex Sander Rodrigues Cangussu
dc.date.accessioned2024-09-23T20:03:57Z
dc.date.accessioned2025-09-08T23:56:43Z
dc.date.available2024-09-23T20:03:57Z
dc.date.issued2023-03-16
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.3390/vaccines11030669
dc.identifier.issn2076-393X
dc.identifier.urihttps://hdl.handle.net/1843/76813
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofVaccines
dc.rightsAcesso Aberto
dc.subjectBactérias anaeróbias
dc.subjectAcinetobacter
dc.subjectInfecções urinarias
dc.subjectImunossupressão
dc.subjectCiclofosfamida
dc.titleUsing an aluminum hydroxide–chitosan matrix increased the vaccine potential and immune response of mice against multi-drug-resistant Acinetobacter baumannii
dc.typeArtigo de periódico
local.citation.issue3
local.citation.spage669
local.citation.volume11
local.description.resumoAcinetobacter baumannii is a Gram-negative, immobile, aerobic nosocomial opportunistic coccobacillus that causes pneumonia, septicemia, and urinary tract infections in immunosuppressed patients. There are no commercially available alternative antimicrobials, and multi-drug resistance is an urgent concern that requires emergency measures and new therapeutic strategies. This study evaluated a multi-drug-resistant A. baumannii whole-cell vaccine, inactivated and adsorbed on an aluminum hydroxide–chitosan (mAhC) matrix, in an A. baumannii sepsis model in immunosuppressed mice by cyclophosphamide (CY). CY-treated mice were divided into immunized, non-immunized, and adjuvant-inoculated groups. Three vaccine doses were given at 0D, 14D, and 28D, followed by a lethal dose of 4.0 × 108 CFU/mL of A. baumannii. Immunized CY-treated mice underwent a significant humoral response, with the highest IgG levels and a higher survival rate (85%); this differed from the non-immunized CY-treated mice, none of whom survived (p < 0.001), and from the adjuvant group, with 45% survival (p < 0.05). Histological data revealed the evident expansion of white spleen pulp from immunized CY-treated mice, whereas, in non-immunized and adjuvanted CY-treated mice, there was more significant organ tissue damage. Our results confirmed the proof-of-concept of the immune response and vaccine protection in a sepsis model in CY-treated mice, contributing to the advancement of new alternatives for protection against A. baumannii infections.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2076-393X/11/3/669

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