Performance and reference intervals of thrombin generation test: results from the brazilian longitudinal study of adult health (elsa-brasil). a cross-sectional study

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dc.creatorDanyelle Romana Alvesrios
dc.creatorSandhi Maria Barreto
dc.creatorLetícia Gonçalves Resende Ferreira
dc.creatorThaís Resende Batista
dc.creatorAna Paula Ferreira Silva
dc.creatorWander Valadares de Oliveira Júnior
dc.creatorChams Bicalho Maluf
dc.creatorMaria Das Gracas Carvalho
dc.creatorRoberta Carvalho Figueiredo
dc.date.accessioned2024-01-19T21:47:33Z
dc.date.accessioned2025-09-09T00:01:46Z
dc.date.available2024-01-19T21:47:33Z
dc.date.issued2022
dc.format.mimetypepdf
dc.identifier.doi10.1590/1516-3180.2021.0425.r1.07102021
dc.identifier.issn18069460
dc.identifier.urihttps://hdl.handle.net/1843/63176
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofSao Paulo Medical Journal
dc.rightsAcesso Aberto
dc.subjectClinical Laboratory Techniques
dc.subjectThrombin
dc.subjectReference Values
dc.subject.otherClinical Laboratory Techniques
dc.subject.otherThrombin
dc.subject.otherReference Values
dc.titlePerformance and reference intervals of thrombin generation test: results from the brazilian longitudinal study of adult health (elsa-brasil). a cross-sectional study
dc.typeArtigo de periódico
local.citation.epage485
local.citation.issue3
local.citation.spage474
local.citation.volume140
local.description.resumoBACKGROUND: The thrombin generation test (TGT) has shown promise for investigation of hemorrhag ic and thrombotic diseases. However, despite its potential, it still needs standardization. Moreover, few studies have established reference values for TGT parameters. In Brazil, these values have not yet been established. OBJECTIVE: To determine TGT performance and reference intervals for TGT parameters in healthy individuals. DESIGN AND SETTING: Cross-sectional study conducted among participants in the Brazilian Longitudinal Study of Adult Health (Estudo Longitudinal de Saúde do Adulto, ELSA-Brasil).METHODS: The reference sample consisted of 620 healthy individuals. The calibrated automated throm bogram (CAT) method, under low and high tissue factor (TF) conditions, was used to assess thrombin generation. Test performance was analyzed using intra and interassay coefficients of variation (CV) and reference intervals were calculated using the nonparametric method proposed by the International Fed eration of Clinical Chemistry and the Clinical and Laboratory Standards Institute. RESULTS: The intraassay CV ranged from 1.4% to 2.2% and the interassay CV, 6.8% to 14.7%. The reference intervals for TGT parameters under low and high TF conditions were, respectively: lagtime: 3.0-10.3 and 1.4-3.7 min; endogenous thrombin potential (ETP): 1134.6-2517.9 and 1413.6-2658.0 nM.min; normalized ETP: 0.6-1.3 and 0.7-1.4; peak: 103.2-397.7 and 256.4-479.0 nM; normalized peak: 0.3-1.3 and 0.7-1.2; and time-to-peak: 5.6-16.0 and 3.4-6.7 min. These parameters were categorized relative to sex. CONCLUSION: TGT performance was adequate and the proposed reference intervals were similar to those of other studies. Our findings may be useful for consolidating the TGT, through contributing to its standardization and validation.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1590/1516-3180.2021.0425.R1.07102021

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