A rare case of an aggressive clear cell variant of calcifying epithelial odontogenic tumor in the posterior maxilla

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dc.creatorJosé Alcides Almeidade Arruda
dc.creatorAline Carvalho Batista
dc.creatorElismauro Franscisco Mendonça
dc.creatorDiego Antônio Costa Arantes
dc.creatorLauren Frenzel Schuch
dc.creatorCarla Mosconi
dc.creatorLucas Guimarães Abreu
dc.creatorBruno Augusto Benevenuto de Andrade
dc.creatorMario José Romañach
dc.creatorRicardo Alves de Mesquita
dc.creatorTarcília Aparecida da Silva
dc.date.accessioned2025-04-11T19:58:39Z
dc.date.accessioned2025-09-09T00:49:12Z
dc.date.available2025-04-11T19:58:39Z
dc.date.issued2020-08
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1177/1066896920901755
dc.identifier.issn1940-2465
dc.identifier.urihttps://hdl.handle.net/1843/81494
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational journal of surgical pathology
dc.rightsAcesso Restrito
dc.subjectGenes
dc.subjectAmyloid
dc.subjectOdontogenic tumors
dc.subjectDiagnosis, differential
dc.subjectMaxilla
dc.subjectKi-67 antigen
dc.subjectKeratins
dc.subjectRecurrence
dc.subject.otherPindborg tumor
dc.subject.otherAmyloid
dc.subject.otherCalcifying epithelial odontogenic tumor
dc.subject.otherDifferential diagnosis
dc.subject.otherMaxilla
dc.subject.otherOdontogenic tumor
dc.titleA rare case of an aggressive clear cell variant of calcifying epithelial odontogenic tumor in the posterior maxilla
dc.typeArtigo de periódico
local.citation.epage535
local.citation.issue5
local.citation.spage526
local.citation.volume28
local.description.resumoA clear cell variant of calcifying epithelial odontogenic tumor is a rare benign odontogenic neoplasm, accounting for 33 cases described in the literature. In this article, we report a challenging example of clear cell variant of calcifying epithelial odontogenic tumor of the posterior maxilla in a 45-year-old female patient showing locally aggressive growth and recurrence. Microscopically, islands of polyhedral cells containing abundant cytoplasm, well-developed intercellular bridges blended with clear cells were observed. The nuclei were frequently pleomorphic and permeated by hyaline calcified material. Immunohistochemistry revealed positivity for pan-cytokeratin (AE1/AE3), cytokeratins (CK-14 and CK-19), Bcl-2, p53, and p63. The Ki-67 proliferative index was ~10%. As odontogenic tumors are rare, when a significant clear cell component is observed, the differential diagnosis with other lesions of the jaws with similar morphology, including other odontogenic tumors with prominent clear cell component, clear cell odontogenic carcinomas, and metastatic tumors, is difficult.
local.identifier.orcidhttps://orcid.org/0000-0002-2117-5593
local.identifier.orcidhttps://orcid.org/0000-0002-6751-3279
local.identifier.orcidhttps://orcid.org/0000-0002-6599-3950
local.identifier.orcidhttps://orcid.org/0000-0002-1306-747X
local.identifier.orcidhttps://orcid.org/0000-0002-0993-936X
local.identifier.orcidhttps://orcid.org/0000-0002-8950-4605
local.identifier.orcidhttps://orcid.org/0000-0003-2258-8071
local.identifier.orcidhttps://orcid.org/0000-0002-7853-5916
local.identifier.orcidhttps://orcid.org/0000-0002-3259-606X
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://journals.sagepub.com/doi/10.1177/1066896920901755?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

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