T-type ca2+ channels and their relationship with pre-neoplastic and neoplastic lesions in the human breast

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dc.creatorF.aguiar
dc.creatorPaula Rhana
dc.creatorEnrrico Bloise
dc.creatorCristiana Buzelin Nunes
dc.creatorA.l. Rodrigues
dc.creatorÊnio Ferreira
dc.date.accessioned2024-10-15T21:47:47Z
dc.date.accessioned2025-09-09T01:26:18Z
dc.date.available2024-10-15T21:47:47Z
dc.date.issued2023
dc.format.mimetypepdf
dc.identifier.doi10.1590/1414-431x2023e11879
dc.identifier.issn1414431X
dc.identifier.urihttps://hdl.handle.net/1843/77456
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso Aberto
dc.subjectBreast cancer
dc.subjectCell Transformation, Neoplastic
dc.subjectCarcinoma in Situ
dc.subject.otherBreast cancer
dc.subject.otherductal hyperplasia
dc.subject.otherT-type voltage-dependent Ca2+ channel
dc.subject.otherCarcinoma in situ
dc.titleT-type ca2+ channels and their relationship with pre-neoplastic and neoplastic lesions in the human breast
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume56
local.description.resumoThe expression of T-type voltage-dependent Ca2+ channels (Cav3) has been previously observed in breast cancer, but their expression and subcellular localization were not evaluated in pre-neoplastic lesions. Therefore, this work aimed to evaluate protein expression and subcellular localization of T-type channel isoforms in human breast tissue samples. Protein expressions of CaV3.1, CaV3.2, and CaV3.3 were evaluated by immunohistochemistry in breast without alteration, in proliferative non-neoplastic lesions, and in neoplastic ductal epithelial lesions of the human breast. CaV3.1, CaV3.2, and CaV3.3 nuclear expressions were decreased in advanced stages of neoplastic transformation, whereas CaV3.1 and CaV3.2 cytoplasmic expression increased. Also, the decrease in nuclear expression was correlated with an increase in cytoplasmic expression for CaV3.1 isoform. The change in CaV3 protein expression and subcellular localization are consistent with the neoplastic transformation stages of mammary epithelial cells, evident in early neoplastic lesions, such as ductal carcinomas in situ. These results suggest a possible involvement of CaV3 in the carcinogenic processes and could be considered as a potential pharmacological target in new therapies for breast cancer treatment.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1590/1414-431X2023e11879

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