Clinicopathological analysis of oral plasmablastic lymphoma: a systematic review

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dc.creatorCarla Isabelly Rodrigues-Fernandes
dc.creatorLucas Lacerda de Souza
dc.creatorSara Ferreira dos Santos Costa
dc.creatorAndré Myller Barbosa Silva
dc.creatorHélder Antônio Rebelo Pontes
dc.creatorMárcio Ajudarte Lopes
dc.creatorOslei Paes de Almeida
dc.creatorPeter Brennan
dc.creatorFelipe Paiva Fonseca
dc.date.accessioned2023-10-05T19:17:06Z
dc.date.accessioned2025-09-09T00:37:10Z
dc.date.available2023-10-05T19:17:06Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1111/jop.12753
dc.identifier.issn09042512
dc.identifier.urihttps://hdl.handle.net/1843/59195
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectEpstein-Barr virus infections
dc.subjectHIV
dc.subjectMouth
dc.subjectPlasmablastic Lymphoma
dc.subjectDrug therapy
dc.subject.otherbusca 09 do 09 2023 fao clínica assunto HIV acesso restrito
dc.titleClinicopathological analysis of oral plasmablastic lymphoma: a systematic review
dc.typeArtigo de periódico
local.citation.epage922
local.citation.spage915
local.citation.volume47
local.description.resumoBackground: Plasmablastic lymphoma (PBL) is a high-grade lymphoma that often affects the oral cavity of HIV-positive patients; however, its prognostic determinants remain unknown. Purpose: To integrate the available data on oral PBL to determine its clinicopathological features and to identify potential prognostic factors. Methods: An electronic systematic review was performed using multiple databases with a specific search strategy in February 2018. Inclusion criteria comprised cases diagnosed as PBL affecting the oral cavity and gnathic bones with sufficient data to confirm the diagnoses. Results: A total of 70 publications were included, representing 153 cases. Oral PBL predominantly affected HIV-positive males (76.4%). EBV was observed in 63.4% of the cases. The gingiva was the most involved site and the lesion usually presented as an asymptomatic swelling. Most cases were classified as stage I (21.6%), and chemotherapy alone was applied in 28.8% of the cases. There was a significant association between HIV and EBV infections, and cases affecting HIV-negative patients were more common in older individuals. Cumulative survival of the patients achieved 42.4% and 33.5% after 2 and 5 years, respectively. Although there were no statistically significant clinicopathological parameters in the univariate analysis, the multivariate Cox regression model demonstrated that EBV-positive status, presence of B-symptoms, and chemotherapy alone were independent prognostic determinants of a poor prognosis. Conclusion: Oral PBL is an aggressive neoplasm with low survival rates, which is influenced by the presence of EBV, presence of B-symptoms, and with the use of chemotherapy only.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12753

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