Occurrence of BMAA isomers in bloom-impacted lakes and reservoirs of Brazil, Canada, France, Mexico, and the United Kingdom

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dc.creatorSafa Abbes
dc.creatorSung Vo Duy
dc.creatorGabriel Munoz
dc.creatorQuoc Tuc Dinh
dc.creatorDana F. Simon
dc.creatorBarry Husk
dc.creatorHelen M. Baulch
dc.creatorBrigitte Vinçon-Leite
dc.creatorNathalie Fortin
dc.creatorCharles W. Greer
dc.creatorMegan L. Larsen
dc.creatorJason J. Venkiteswaran
dc.creatorFelipe Fernando Martínez Jerónimo
dc.creatorAlessandra Giani
dc.creatorChris D. Lowe
dc.creatorNicolas Tromas
dc.creatorSébastien Sauvé
dc.date.accessioned2023-10-27T21:07:54Z
dc.date.accessioned2025-09-09T00:05:19Z
dc.date.available2023-10-27T21:07:54Z
dc.date.issued2022
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/toxins14040251
dc.identifier.issn2072-6651
dc.identifier.urihttps://hdl.handle.net/1843/60195
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofToxins
dc.rightsAcesso Aberto
dc.subjectLagos
dc.subjectCianobactérias
dc.subjectToxinas de cianobactérias
dc.subject.otherLake water
dc.subject.otherβ-N-methyl-amino-l-alanine (BMAA)
dc.subject.other2,4-diaminobutyric acid (DAB)
dc.subject.otherN-(2- aminoethyl) glycine (AEG)
dc.subject.otherTrichloroacetic acid (TCA)
dc.subject.otherTemporal trends
dc.titleOccurrence of BMAA isomers in bloom-impacted lakes and reservoirs of Brazil, Canada, France, Mexico, and the United Kingdom
dc.title.alternativeOcorrência de isômeros BMAA em lagos e reservatórios afetados pelo florescimento do Brasil, Canadá, França, México e Reino Unido
dc.typeArtigo de periódico
local.citation.issue4
local.citation.volume14
local.description.resumoThe neurotoxic alkaloid β-N-methyl-amino-l-alanine (BMAA) and related isomers, including N-(2-aminoethyl glycine) (AEG), β-amino-N-methyl alanine (BAMA), and 2,4-diaminobutyric acid (DAB), have been reported previously in cyanobacterial samples. However, there are conflicting reports regarding their occurrence in surface waters. In this study, we evaluated the impact of amending lake water samples with trichloroacetic acid (0.1 M TCA) on the detection of BMAA isomers, compared with pre-existing protocols. A sensitive instrumental method was enlisted for the survey, with limits of detection in the range of 5–10 ng L−1. Higher detection rates and significantly greater levels (paired Wilcoxon’s signed-rank tests, p < 0.001) of BMAA isomers were observed in TCA-amended samples (method B) compared to samples without TCA (method A). The overall range of B/A ratios was 0.67–8.25 for AEG (up to +725%) and 0.69–15.5 for DAB (up to +1450%), with absolute concentration increases in TCA-amended samples of up to +15,000 ng L−1 for AEG and +650 ng L−1 for DAB. We also documented the trends in the occurrence of BMAA isomers for a large breadth of field-collected lakes from Brazil, Canada, France, Mexico, and the United Kingdom. Data gathered during this overarching campaign (overall, n = 390 within 45 lake sampling sites) indicated frequent detections of AEG and DAB isomers, with detection rates of 30% and 43% and maximum levels of 19,000 ng L−1 and 1100 ng L−1, respectively. In contrast, BAMA was found in less than 8% of the water samples, and BMAA was not found in any sample. These results support the analyses of free-living cyanobacteria, wherein BMAA was often reported at concentrations of 2–4 orders of magnitude lower than AEG and DAB. Seasonal measurements conducted at two bloom-impacted lakes indicated limited correlations of BMAA isomers with total microcystins or chlorophyll-a, which deserves further investigation.
local.identifier.orcidhttps://orcid.org/0000-0003-3725-2482
local.identifier.orcidhttps://orcid.org/0000-0001-9018-4998
local.identifier.orcidhttps://orcid.org/0000-0002-0190-0209
local.identifier.orcidhttps://orcid.org/0000-0003-1484-9817
local.identifier.orcidhttps://orcid.org/0000-0002-2524-8534
local.identifier.orcidhttps://orcid.org/0000-0001-8584-1690
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BOTÂNICA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2072-6651/14/4/251

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