Pigmented lesions of the oral mucosa: a cross-sectional study of 458 histopathological specimens

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dc.creatorThalita Soares Tavares
dc.creatorDaniela Pereira Meirelles
dc.creatorMaria Cássia Ferreira de Aguiar
dc.creatorPatrícia Carlos Caldeira
dc.date.accessioned2025-07-10T21:06:28Z
dc.date.accessioned2025-09-09T01:00:41Z
dc.date.available2025-07-10T21:06:28Z
dc.date.issued2018-11
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/odi.12924
dc.identifier.issn1601-0825
dc.identifier.urihttps://hdl.handle.net/1843/83492
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Diseases
dc.rightsAcesso Restrito
dc.subjectDental amalgam
dc.subjectMelanins
dc.subjectMouth mucosa
dc.subjectPigmentation
dc.subjectMacular pigment
dc.subjectNeuroectodermal tumor, melanotic
dc.subjectNevus, pigmented
dc.subjectDiagnosis
dc.subjectMelanoma
dc.subjectMelanosis
dc.subjectMetals, heavy
dc.subject.otherDental amalgam
dc.subject.otherMelanins
dc.subject.otherMouth mucosa
dc.subject.otherNevus
dc.subject.otherOral lesions
dc.subject.otherPigmentation
dc.titlePigmented lesions of the oral mucosa: a cross-sectional study of 458 histopathological specimens
dc.typeArtigo de periódico
local.citation.epage1491
local.citation.issue8
local.citation.spage1484
local.citation.volume24
local.description.resumoObjectives: To evaluate clinical, demographic, and histopathological characteristics of pigmented lesions of the oral mucosa. Materials and methods: A cross-sectional study was conducted over a 64-year period. Information was collected from medical charts, and all archived histopathological specimens with diagnoses of any pigmented lesion were retrieved. Statistical analysis was performed using SPSS software. Results: A total of 34,127 archived specimens were reviewed, revealing 458 (1.34%) pigmented lesions, of which 230 were melanocytic and 228 nonmelanocytic. Most patients were females (74.2%), white-skinned (49.1%), in the third and seventh decades of life (mean of 45 years). Most lesions were macular (59.8%), followed by plaques and nodules (4.8%), measuring 0-5 mm (41.9%). Cheek mucosa (21.0%), alveolar mucosa (16.6%), and gingiva (11.8%) were the most commonly affected sites. Amalgam tattoo was applied in 212 cases (46.3%), followed by melanotic macule (22.9%) and nevus (20.5%). Other diagnoses included racial pigmentation, exogenous pigmentation, melanotic neuroectodermal tumor of infancy, melanoma, melanoacanthoma, smoker's melanosis, and heavy metal pigmentation. Conclusions: Pigmented lesions represent an uncommon diagnosis in oral pathology routines. The most frequent entities are amalgam tattoo, melanotic macule, and nevus. Patients are usually middle-aged women presenting a small, long-lasting, macular lesion on the cheek mucosa.
local.identifier.orcidhttps://orcid.org/0000-0001-7220-1360
local.identifier.orcidhttps://orcid.org/0000-0001-5134-3466
local.identifier.orcidhttps://orcid.org/0000-0002-9179-0145
local.identifier.orcidhttps://orcid.org/0000-0002-4698-3992
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/odi.12924

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