Is the “lactormone” a key-factor for exercise-related neuroplasticity? A hypothesis based on an alternative lactate neurobiological pathway

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dc.creatorRenato Sobral Monteiro Junior
dc.creatorPauline Maillot
dc.creatorValeska Gatica-Rojas
dc.creatorWaldney Roberto de Matos e Ávila
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.creatorSergio Henrique Sousa Santos
dc.creatorCamila Castelo Branco Pupe
dc.creatorAndréa Camaz Deslandes
dc.date.accessioned2022-08-22T15:10:08Z
dc.date.accessioned2025-09-08T23:53:42Z
dc.date.available2022-08-22T15:10:08Z
dc.date.issued2019-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.identifier.doihttps://doi.org/10.1016/j.mehy.2018.12.013
dc.identifier.issn0306-9877
dc.identifier.urihttps://hdl.handle.net/1843/44446
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMedical Hypotheses
dc.rightsAcesso Aberto
dc.subjectLactatos
dc.subjectÁcido pirúvico
dc.subjectExercícios físicos
dc.subjectNeuroplasticidade
dc.subjectGlicose
dc.subjectNeurociências
dc.titleIs the “lactormone” a key-factor for exercise-related neuroplasticity? A hypothesis based on an alternative lactate neurobiological pathway
dc.typeArtigo de periódico
local.citation.epage66
local.citation.spage63
local.citation.volume123
local.description.resumoFor many years lactate was seen as a metabolite from glucose metabolism. However, since the last century researchers have shown that this molecule has an important role on liver, muscle, and brain metabolism. Lactate traffics along whole body mediating many biological processes depending on specific situations. For example, glucose is the main substrate used during exercise but lactate released by striated skeletal muscle is used by own muscle as secondary fuel. On the other hand, neuronal firing in the brain is almost totally lactate-dependent. In addition, lactate has an important role on BDNF-mediated neuroplasticity. As this molecule has a pleiotropic role in the body, it was called as “lactormone” in 2009. Here we show basic concepts on peripheral and central metabolism and discuss neurobiological pathways of lactate, including an alternative hypothesis on lactate released during exercise.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0306987718310946?via%3Dihub

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