The anti-caries activity and toxicity of an experimental propolis-containing varnish

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dc.creatorMariana Passos de Luca
dc.creatorIrlan Almeida Freires
dc.creatorAlfonso Gala Garcia
dc.creatorVagner Rodrigues Santos
dc.creatorMiriam Parreira Pimenta do Vale
dc.creatorSeverino Matias de Alencar
dc.creatorPedro Luiz Rosalen
dc.date.accessioned2025-06-24T21:47:23Z
dc.date.accessioned2025-09-08T23:31:09Z
dc.date.available2025-06-24T21:47:23Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1807-3107BOR-2017.vol31.0045
dc.identifier.issn1807-3107
dc.identifier.urihttps://hdl.handle.net/1843/83114
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Oral Research
dc.rightsAcesso Aberto
dc.subjectPropolis
dc.subjectStreptococcus mutans
dc.subjectDental caries
dc.subjectModels animal
dc.subjectFibroblasts
dc.subjectPharmacological and toxicological phenomena
dc.subjectDental enamel
dc.subjectDentin
dc.subject.otherPropolis
dc.subject.otherStreptococcus mutans
dc.subject.otherDental caries
dc.subject.otherModels
dc.subject.otherAnimal
dc.titleThe anti-caries activity and toxicity of an experimental propolis-containing varnish
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume31
local.description.resumoWe investigated the anti-caries effects of an experimental propolis varnish in vivo, and further tested its toxicity against fibroblasts. Fifty-six SPF female Wistar rats were infected with Streptococcus mutans UA159 (SM) and allocated into four groups (n = 14/group): G1, propolis varnish (15%/PV); G2, chitosan varnish (CV/vehicle); G3, gold standard (GS/Duraphat®); and G4, untreated. The animals received a single varnish application on their molars and were submitted to a high cariogenic challenge (Diet-2000, 56% sucrose, and 5% sucrose-added water, ad libitum) for 4 weeks. Total cultivable microbiota and SM were counted, and smooth-surface and sulcal caries were scored. PV, CV and GS cytotoxic effects were tested against fibroblasts. The data were analyzed using ANOVA with the Tukey-Kramer test (p ≤ 0.05). Total microbiota and SM counts did not differ among the treatments (p = 0.78), or in relation to the untreated group (p = 0.52). PV reduced development of smooth-surface enamel caries compared with the untreated group (p = 0.0018), with no significant difference from GS (p = 0.92); however, the PV effects were no longer observed when the dentin was affected. Neither PV nor GS prevented enamel sulcal lesion onset, but GS significantly reduced the severity of dentinal sulcal lesions (p < 0.0001). No significant difference was observed in fibroblast viability between PV and GS (p < 0.0001). In conclusion, PV prevented smooth-surface enamel caries and showed low cell toxicity. Nevertheless, due to the high cariogenic challenge, its effects were not sustained throughout the experiment. Further studies are encouraged to establish a protocol to sustain the long-term anti-caries activity of PV in the oral cavity.
local.identifier.orcidhttps://orcid.org/0000-0001-7995-4218
local.identifier.orcidhttps://orcid.org/0000-0002-1079-6941
local.identifier.orcidhttps://orcid.org/0000-0002-3934-1094
local.identifier.orcidhttps://orcid.org/0000-0002-5370-4867
local.identifier.orcidhttps://orcid.org/0000-0002-8781-778X
local.identifier.orcidhttps://orcid.org/0000-0002-6637-7973
local.identifier.orcidhttps://orcid.org/0000-0003-0812-4027
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bor/a/WTgHPPrK3kTwkv6VwCkwjMM/

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