Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk

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dc.creatorMilena Maria Moreira Guimarães
dc.creatorDirceu Bartolomeu Greco
dc.creatorAllyson Nogueira Moreira
dc.creatorNathalia Sernizon Guimarães
dc.creatorCláudia Maria Vilas Freire
dc.creatorBruna Guimarães Rohlfs
dc.creatorLucas José de Campos Machado
dc.date.accessioned2023-07-24T20:28:57Z
dc.date.accessioned2025-09-08T23:03:39Z
dc.date.available2023-07-24T20:28:57Z
dc.date.issued2018-04-22
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.bjid.2018.03.006
dc.identifier.issn14138670
dc.identifier.urihttps://hdl.handle.net/1843/56916
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofThe Brazilian Journal of Infectious Diseases
dc.rightsAcesso Aberto
dc.subjectHiperlipidemia
dc.subjectAterosclerose
dc.subjectFatores de Risco de Doenças Cardíacas
dc.subjectResistência à Insulina
dc.subjectHIV
dc.subject.otherHIV
dc.subject.otherHyperlipidemia
dc.subject.otherAtherosclerosis
dc.subject.otherLipid accumulation product index
dc.subject.otherCardiovascular risk
dc.subject.otherInsulin resistance
dc.titleLipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk
dc.typeArtigo de periódico
local.citation.epage176
local.citation.issue3
local.citation.spage171
local.citation.volume22
local.description.resumoThe lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted atthe outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels. Body mass index (BMI) was similar in both groups; how ever, waist circumference was greater in the HIV-infected patients. Triglyceride levels were significantly higher (p < 0.001) and HDL cholesterol levels were lower in HIV-infected patients (p < 0.001). Plasma glucose (p = 0.01) and insulin (p = 0.005) levels two hours after a glucose load, HOMA-IR index (p < 0.001) and LAP index (p < 0.001) were higher in the HIV-infected patients. A positive and significant correlation was found between HOMA-IR index and LAP (r = 0.615; p < 0.01), BMI (r = 0.334; p < 0.01) and waist circumference (r = 0.452; p < 0.01) in the HIV-infected patients. In male HIV-infected patients and controls, ROC curve analyses revealed that the best cut-off value of LAP to define the presence of insulin resistance was 64.8 (sensitivity 86%, specificity 77% and area under the curve 0.824). These results confirm that insulin resistance is more common in HIV-patients on antiretroviral drugs than in HIV negative controls. A positive and significant correlation was found between the LAP index and the HOMA index, with LAP ≥ 64.8 constituting an additional risk factor for cardiovascular disease in male HIV patients.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1413867018300199?via%3Dihub

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