Reactivation of latent HIV-1 in vitro using an ethanolic extract from Euphorbia umbellata (Euphorbiaceae) latex

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dc.creatorAna Luiza Chaves Valadão
dc.creatorPaulo Damasco
dc.creatorGabriel Gonçalves
dc.creatorRui Manuel Reis
dc.creatorRenato Santana de Aguiar
dc.creatorCleonice Alves de Melo Bento
dc.creatorAmilcar Tanuri
dc.creatorPaula Pezzuto
dc.creatorViviane A. Oliveira Silva
dc.creatorBarbara Simonson Gonçalves
dc.creatorÁtila Duque Rossi
dc.creatorRodrigo Delvecchio da Cunha
dc.creatorAntonio Carlos Siani
dc.creatorJoão Batista de Freitas Tostes
dc.creatorMarcelo Trovó
dc.date.accessioned2023-07-17T18:06:17Z
dc.date.accessioned2025-09-08T23:17:19Z
dc.date.available2023-07-17T18:06:17Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0207664
dc.identifier.urihttps://hdl.handle.net/1843/56423
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPLOS ONE
dc.rightsAcesso Aberto
dc.subjectEuforbiacea
dc.subjectInfecções por HIV
dc.subjectLatex
dc.subject.otherEuphorbia umbellata
dc.subject.otherHIV infection
dc.subject.otherLatex extract
dc.titleReactivation of latent HIV-1 in vitro using an ethanolic extract from Euphorbia umbellata (Euphorbiaceae) latex
dc.typeArtigo de periódico
local.citation.issue11
local.citation.volume13
local.description.resumoEuphorbia umbellata (E. umbellata) belongs to Euphorbiaceae family, popularly known as Janauba, and its latex contains a combination of phorbol esters with biological activities described to different cellular protein kinase C (PKC) isoforms. Here, we identified deoxi-phorbol esters present in E. umbellata latex alcoholic extract that are able to increase HIV transcription and reactivate virus from latency models. This activity is probably mediated by NF-kB activation followed by nuclear translocation and binding to the HIV LTR promoter. In addition, E. umbellata latex extract induced the production of pro inflammatory cytokines in vitro in human PBMC cultures. This latex extract also activates latent virus in human PBMCs isolated from HIV positive patients as well as latent SIV in non-human primate primary CD4+ T lymphocytes. Together, these results indicate that the phorbol esters present in E. umbellata latex are promising candidate compounds for future clinical trials for shock and kill therapies to promote HIV cure and eradication.
local.identifier.orcidhttp://orcid.org/0000-0002-9639-7940
local.identifier.orcidhttps://orcid.org/0000-0001-5180-3717
local.identifier.orcidhttps://orcid.org/0000-0001-9570-8244
local.identifier.orcidhttps://orcid.org/0000-0001-5919-5242
local.identifier.orcidhttps://orcid.org/0000-0002-9378-0418
local.identifier.orcidhttps://orcid.org/0000-0001-6235-8807
local.identifier.orcidhttps://orcid.org/0000-0002-2951-3964
local.identifier.orcidhttps://orcid.org/0000-0001-8108-2500
local.identifier.orcidhttps://orcid.org/0000-0002-0478-2332
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207664

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