Schistosoma mansoni infection is impacted by malnutrition

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dc.creatorPoliane Silva Maciel
dc.creatorRicardo Gonçalves
dc.creatorLis Ribeiro do Valle Antonelli
dc.creatorCristina Toscano Fonseca
dc.date.accessioned2023-09-14T19:13:35Z
dc.date.accessioned2025-09-09T00:44:09Z
dc.date.available2023-09-14T19:13:35Z
dc.date.issued2021
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fmicb.2021.635843
dc.identifier.issn1664-302X
dc.identifier.urihttps://hdl.handle.net/1843/58679
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Microbiology
dc.rightsAcesso Aberto
dc.subjectDieta com Restrição de Proteínas
dc.subjectDesnutrição
dc.subjectEsquistossomose
dc.subject.otherSchistosomiasis
dc.subject.otherS. mansoni
dc.subject.otherMalnutrition
dc.subject.otherLow-protein diet
dc.titleSchistosoma mansoni infection is impacted by malnutrition
dc.typeArtigo de periódico
local.citation.epage12
local.citation.spage635843
local.citation.volume12
local.description.resumoSchistosomiasis remains one of the most important neglected tropical diseases in the world. It mainly affects developing countries, where it often coexists with malnutrition. Despite this, few studies have investigated the relationship between schistosomiasis and malnutrition. Herein, we evaluate the impact of malnutrition on experimental S. mansoni infection. Mice were divided into 5 groups: Control (Ctrl) diet (14% protein and 10% lipids), low-protein 3% (LP 3%), low-protein 8% (LP 8%), low-fat 2.5% (LF 2.5%), and low-fat 5% (LF 5%). Mice were fed with their respective diets and were infected when a difference of approximately 20% in the body weight between mice from any experimental group and mice from the control group was achieved. Nutritional, parasitological, and immunological parameters were assessed either just before infection and/or approximately 50 days later before mice were perfused. Our results showed that the 3% low-protein diet was the only one capable of establishing malnutrition in mice. Mice fed with this diet showed: (i) significant reduction in body weight and serum albumin levels before infection, (ii) decreased levels of all biochemical parameters evaluated before perfusion, (iii) decreased numbers of schistosome eggs trapped in intestines and impaired parasite fecundity, (iv) a delay in the granuloma development with a smaller granuloma area, and (v) reduced levels of IL-4 and IFN-γ in the liver. Our findings demonstrate that low protein supply leads to malnutrition in mice and impacts the cytokine milieu in the liver and granuloma formation. Additionally, the establishment of our murine malnutrition model will enable future studies aiming to better understand the complex relationships between nutrition, immune responses, and infection outcome.
local.identifier.orcidhttps://orcid.org/0000-0002-1127-4483
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fmicb.2021.635843/full

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