Canine and feline uveal melanocytic tumours: Histologic and immunohistochemical characteristics of 32 cases

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dc.creatorMatheus Vilardo Lóes Moreira
dc.creatorIngeborg Maria Langohr
dc.creatorMarina Rios de Araújo Campos
dc.creatorEnio Ferreira
dc.creatorBárbara Carvalho
dc.creatorGuilherme Reis Blume
dc.creatorFabiano Montiani-Ferreira
dc.creatorRoselene Ecco
dc.date.accessioned2023-10-31T21:35:58Z
dc.date.accessioned2025-09-09T00:53:59Z
dc.date.available2023-10-31T21:35:58Z
dc.date.issued2022-02-05
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1002/vms3.752
dc.identifier.issn2053-1095
dc.identifier.urihttps://hdl.handle.net/1843/60397
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofVeterinary Medicine and Science
dc.rightsAcesso Aberto
dc.subjectMedicina Veterinária
dc.subjectTumores
dc.subjectGatos
dc.subjectMelanoma
dc.subjectApoptose
dc.subject.otherApoptosis
dc.subject.otherGlobe
dc.subject.otherImmunohistochemistry
dc.subject.otherMelanocytoma
dc.subject.otherMelanoma
dc.subject.otherTumour aggressiveness factors
dc.titleCanine and feline uveal melanocytic tumours: Histologic and immunohistochemical characteristics of 32 cases
dc.typeArtigo de periódico
local.citation.epage1048
local.citation.issue3
local.citation.spage1036
local.citation.volume8
local.description.resumoObjective Gross, histopathological, and immunohistochemical characteristics of uveal melanocytic neoplasms in dogs and cats were investigated. Samples Thirty-two enucleated globes with uveal melanocytic neoplasms, 27 from dogs and 5 from cats, were examined. Procedures Morphological characteristics of uveal melanocytic neoplasms in dogs and cats were evaluated with anti-PNL2, anti-Melan-A, anti-Ki-67, anti-caspase-3, and anti-BAP1 immunomarkers. Statistical analysis was performed to compare canine melanocytomas and melanomas. Results The 32 uveal neoplasms were classified as melanocytomas (19/27 in dogs) or melanomas (8/27 in dogs, 5/5 in cats). Most tumours (84%) were located in the anterior uvea. Neoplastic cells were classified as epithelioid, spindle-shaped, mixed, or special type (balloon and signet ring cells). The percentage of cells with melanin, melanin concentration within cells, anisocytosis and anisokaryosis, mitotic count, lymphocytic inflammation, necrosis, vascular invasion, and glaucoma were also characterized. Anisocytosis, percentage of neoplastic cells with melanin, mitotic count, and indices (proliferation and apoptotic) varied significantly between canine uveal melanomas and melanocytomas; in general, melanomas had greater cell variability, were less pigmented, and had a higher mitotic count. The melanocytic origin of the neoplasms was confirmed by positive anti-PNL2 immunolabelling (29/32) and positive anti-Melan-A immunolabelling (3/32). In canine uveal melanomas, anisocytosis and anisokaryosis correlated with less pigmentation and minimal pigmentation correlated with a high percentage of immunolabelling for caspase-3. Conclusions Uveal melanocytomas were more common in dogs, and uveal melanomas were more frequent in cats. Anisocytosis, percentage of neoplastic cells with melanin, and mitotic count are important histologic characteristics of malignancy to evaluate in uveal melanocytic neoplasms. The proliferation and apoptotic indices are relevant when comparing malignant tumours with benign tumours.
local.identifier.orcidhttps://orcid.org/0000-0003-0173-3524
local.identifier.orcidhttps://orcid.org/0000-0001-7366-4391
local.identifier.orcidhttps://orcid.org/0000-0002-8052-5389
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/vms3.752

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