Menstrual cycle and hemostatic modifications: a review

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dc.creatorLetícia Gonçalves Freitas
dc.creatorCristina de Mello Gomide Loures
dc.creatorMarcos Vinícius Ferreira Silva Marcos
dc.creatorFernanda Freire Campos Nunes
dc.creatorMaria Das Gracas Carvalho
dc.creatorLuci Maria SantAna Dusse
dc.date.accessioned2022-03-04T13:39:29Z
dc.date.accessioned2025-09-08T22:52:55Z
dc.date.available2022-03-04T13:39:29Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttp://www.ijhsr.org/IJHSR_Vol.6_Issue.6_June2016/52.pdf
dc.identifier.issn2249-9571
dc.identifier.urihttps://hdl.handle.net/1843/39792
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Health Sciences and Research
dc.rightsAcesso Aberto
dc.subjectCiclo menstrual
dc.subjectMenstruação
dc.subjectFenômenos fisiológicos
dc.subject.otherMenstrual cycle
dc.subject.otherHemostatic modifications
dc.subject.otherMenstruation physiology
dc.titleMenstrual cycle and hemostatic modifications: a review
dc.typeArtigo de periódico
local.citation.epage328
local.citation.issue6
local.citation.spage320
local.citation.volume6
local.description.resumoPhysiologically, menstrual cycle is a complex process involving cell replication and growth under the influence of hormones, growth factors, neurotransmitters, regulatory molecules and hemostatic mechanisms. During this process, there is platelet aggregate formation, coagulation cascade activation, synthesis and activation of various procoagulant molecules and fibrin clot formation, aiming to control bleeding. Subsequently, activation of the fibrinolytic system is observed for remodeling the tissue. This review considers articles that evaluated hemostatic and hematological alterations during menstrual cycle in order to better understand this physiological process. There is evidence that menstrual cycle is associated with procoagulant (platelet aggregation, coagulation factors and fibrinolysis inhibitors) and anticoagulant (fibrinolysis system activators) changes. However, data are still conflicting for each phase. Current literature confirms that the most important modifications in hemostasis occur due to the fundamental role of progesterone, although follicular and bleeding phases also take place with a balance between the pro and anticoagulant factors. Additional randomized and well controlled clinical studies are required to clarify thehemostatic changes and its consequences in women health.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.52403/ijhsr

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