Multiple Sclerosis in Pregnancy and its Role in Female Fertility: A Systematic Review

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dc.creatorRívia Mara Lamaita
dc.creatorCarolina Melo
dc.creatorCláudia Lourdes Soares Laranjeira
dc.creatorPaula Barquero
dc.creatorJoyce Gomes
dc.creatorAgnaldo Lopes da Silva Filho
dc.date.accessioned2023-08-08T23:12:56Z
dc.date.accessioned2025-09-08T23:37:23Z
dc.date.available2023-08-08T23:12:56Z
dc.date.issued2021-02-15
dc.format.mimetypepdf
dc.identifier.doihttps://10.5935/1518-0557.20210022
dc.identifier.issn1518-0557
dc.identifier.urihttps://hdl.handle.net/1843/57632
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJBRA Assisted Reproduction
dc.rightsAcesso Aberto
dc.subjectEsclerose Múltipla
dc.subjectGravidez
dc.subjectFertilidade
dc.subjectRevisão Sistemática
dc.subject.otherMultiple sclerosis
dc.subject.otherPregnancy
dc.subject.otherFertility
dc.subject.otherSystematic review
dc.titleMultiple Sclerosis in Pregnancy and its Role in Female Fertility: A Systematic Review
dc.typeArtigo de periódico
local.citation.epage497
local.citation.issue3
local.citation.spage493
local.citation.volume25
local.description.resumoMultiple sclerosis (MS) is a neurological disease that typically affects young women of reproductive age. There are still many questions and heterogeneous clinical approaches partly due to the lack of consensus and guidelines. For many years, women with MS have been discouraged from getting pregnant for fears that the disease might negatively affect the fetus or increase their obstetric risk or for claims that the disease might decrease fertility. However, fertility does not seem to be impaired to a larger extent in women with MS. Therefore, all healthcare providers involved in the follow-up of multiple sclerosis patients must be prepared to discuss future fertility, pregnancy, and others matters, in addition to providing them with the best possible counseling. This study presents data based on updated evidence and discusses fertility and pregnancy in patients with MS with respect to the impacts of pregnancy on the risk and prognostic factors tied to MS, and the impact of MS on pregnancy outcomes and fertility treatments administered to females with MS. In conclusion, a clear relationship between infertility and MS has not been established. There seems to exist a link between disease aggressiveness and progression with several processes that might impair fertility. However, MS does not stand as a contraindication to assisted reproductive technology. From the several studies analyzed, it is possible to conclude that pregnancy is possible in women with MS. It is important to discuss and plan the ideal moment to start treatment and managing pregnancy and contraception aiming at better results.
local.identifier.orcidhttps://orcid.org/0000-0002-9389-3316
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
local.publisher.initialsUFMG

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