Covid-19 outcomes in people living with hiv: peering through the waves

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dc.creatorThaís Lorenna Souzasales
dc.creatorLucas Emanuel Ferreira Ramos
dc.creatorAlexandre Vargas Schwarzbold
dc.creatorAlzira de Oliveira Jorge
dc.creatorAna Luiza Bahia Alves Scotton
dc.creatorBruno Mateus de Castro
dc.creatorCarla Thais Cândida Alves da Silva
dc.creatorCarolina Marques Ramos
dc.creatorFernando Anschau
dc.creatorFernando Antonio Botoni
dc.creatorGenna Maira Santos Grizende
dc.creatorMaíra Viana Rego Souza-silva
dc.creatorMatheus Carvalho Alves Nogueira
dc.creatorPolianna Delfino-pereira
dc.creatorJoão Victor Baroni Neves
dc.creatorManuela Furtado Sacioto
dc.creatorVivian Costa Morais de Assis
dc.creatorHelena Duani
dc.creatorNeimy Ramos de Oliveira
dc.creatorNatália da Cunha Severino Sampaio
dc.date.accessioned2025-06-05T20:50:01Z
dc.date.accessioned2025-09-09T00:59:53Z
dc.date.available2025-06-05T20:50:01Z
dc.date.issued2023
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.clinsp.2023.100223
dc.identifier.issn18075932
dc.identifier.urihttps://hdl.handle.net/1843/82839
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinics
dc.rightsAcesso Aberto
dc.subjectCOVID-19
dc.subjectHIV-1
dc.subjectIntensive Care Units
dc.subjectVentilators, Mechanical
dc.subjectMortality
dc.subject.otherCOVID-19
dc.subject.otherHIV-1
dc.subject.otherIntensive Care Units
dc.subject.otherVentilators, Mechanical
dc.subject.otherMortality
dc.titleCovid-19 outcomes in people living with hiv: peering through the waves
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume78
local.description.resumoObjective: To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods: This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher’s Exact tests for categorical variables and the Wilcoxon for numerical variables. Results: Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%;p> 0.999).Conclusions: Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE ESTATÍSTICA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/clin/a/99YgBMXWM3tk8MF5syg5f4w/?format=pdf

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