Síntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicas

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dc.creatorCarmindo R. Borel
dc.creatorLuiz Cláudio de Almeida Barbosa
dc.creatorCélia Maltha
dc.creatorSergio Fernandes
dc.creatorLarissa Santos
dc.creatorJacqueline Takahashi
dc.date.accessioned2023-10-09T23:01:55Z
dc.date.accessioned2025-09-09T01:13:06Z
dc.date.available2023-10-09T23:01:55Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.21577/0100-4042.20170118
dc.identifier.issn0100-4042
dc.identifier.urihttps://hdl.handle.net/1843/59321
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofQuímica Nova
dc.rightsAcesso Aberto
dc.subjectMicroondas
dc.subjectAtividade antifúngicas
dc.subject.otherPyridylquinoline
dc.subject.otherAntifungal
dc.subject.otherPovarov reaction
dc.subject.otherCycloaddition
dc.subject.otherCandida spp
dc.titleSíntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicas
dc.title.alternativeSynthesis of 2-(2-pyridyl)quinolines promoted mby microwaves and their antigungal activities
dc.typeArtigo de periódico
local.citation.epage1073
local.citation.issue9
local.citation.spage1065
local.citation.volume40
local.description.resumoIn this work a series of 2-(2- pyridyl)quinolines were prepared via a Povarov reaction between anilines, 2-pyridinocarbadehyde and ethyl vinyl ether under microwaves heating conditions. The optimized conditions herein reported allowed the preparation of several pyridylquinolines in yields in the range of 30-83%, some of them not previously accessible by this multicomponent process. The reported methodology has advantage over previous report due to its larger scope and short reaction time (2 hours). All quinolines obtained were assayed against five species of clinically important yeasts Candida sp and against Cryptococcus neoformans. Some of them possessed a broad spectrum of action including 2-(2-pyridyl)quinoline (20) and 6,8-dimethoxy-2-(pyridin-2-yl)quinolone (22) that were highly effective in inhibiting Candida species (IC50 < 1.95 µg/mL against C. tropicalis and C. krusei). Some compounds were more potent than commercial drugs Nistatin and Miconazole.
local.identifier.orcidhttps://orcid.org/0000-0002-5395-9608
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/qn/a/jc7LwYFcTfXr3ztJ5YjZhpv/

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