Craniopharyngiomas and odontogenic tumors mimic normal odontogenesis and share genetic mutations, histopathological features and molecular pathways activation

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dc.creatorCarolina Cavalierigomes
dc.creatorSílvia Ferreira de Sousa
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-07-02T19:12:43Z
dc.date.accessioned2025-09-08T22:55:55Z
dc.date.available2025-07-02T19:12:43Z
dc.date.issued2019-03
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2018.11.004
dc.identifier.issn2212-4411
dc.identifier.urihttps://hdl.handle.net/1843/83294
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Restrito
dc.subjectMutation
dc.subjectGenes
dc.subjectCraniopharyngioma
dc.subjectTherapeutics
dc.subjectOdontogenic tumors
dc.titleCraniopharyngiomas and odontogenic tumors mimic normal odontogenesis and share genetic mutations, histopathological features and molecular pathways activation
dc.typeArtigo de periódico
local.citation.epage236
local.citation.issue3
local.citation.spage231
local.citation.volume127
local.description.resumoOdontogenic tumors bear some histopathologic and molecular resemblance to craniopharyngiomas. Specifically, adamantinomatous craniopharyngioma shares morphologic features and CTNNB1 (the gene encoding β-catenin) mutations with calcifying odontogenic cyst, whereas papillary craniopharyngioma and ameloblastoma are driven by BRAF mutations. Recently, important similarities between adamantinomatous craniopharyngioma and the cell signaling pathways involved in tooth formation have been described. Here, we expand the interpretation of these data in the context of odontogenic tumors. We discuss some morphologic and molecular features that are shared by tumors from these 2 distinct sites (i.e., craniopharyngiomas and odontogenic tumors). Current conservative surgical treatment is effective in most cases of benign odontogenic tumors, but in the future, the understanding of the molecular pathogenesis could impact the treatment of aggressive and/or malignant cases.
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0001-7820-4749
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440318312422?via%3Dihub#ack0001

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