Local tissue electrical parameters predict oral mucositis in HNSCC patients: a diagnostic accuracy double-blind, randomized controlled trial

Página do item simplificado
dc.creatorGabriela Luize Guimarães Sanches
dc.creatorAgna Soares da Silva Menezes
dc.creatorLaércio Ives Santos
dc.creatorCristina Paixão Durães
dc.creatorLarissa Lopes Fonseca
dc.creatorMarcelo Perim Baldo
dc.creatorThais de Oliveira Faria
dc.creatorLuciano Alves de Araújo Andrade
dc.creatorPetr Iakovlevitch Ekel
dc.creatorSérgio Henrique Sousa Santos
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorLucyana Conceição Farias
dc.creatorMarcos Flávio Silveira Vasconcelos D’Angelo
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2022-09-05T14:58:57Z
dc.date.accessioned2025-09-09T00:18:52Z
dc.date.available2022-09-05T14:58:57Z
dc.date.issued2020-06-12
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1038/s41598-020-66351-9
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/44908
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.subjectCarcinoma de células escamosas
dc.subjectCâncer - Radioterapia
dc.subjectEletroterapia
dc.titleLocal tissue electrical parameters predict oral mucositis in HNSCC patients: a diagnostic accuracy double-blind, randomized controlled trial
dc.typeArtigo de periódico
local.citation.issue1
local.citation.spage9530
local.citation.volume10
local.description.resumoOral Mucositis (OM) is a common adverse effect of head and neck squamous cell carcinoma (HNSCC) treatment. The purpose of this study was to investigate the significance of early changes in tissue electrical parameters (TEPs) in predicting the development of OM in HNSCC patients receiving radiation therapy (RT). The current study combined two study designs. The first was a case-control study. The control group comprised of RT patients who did not receive head and neck RT, and patients with HNSCC who received RT comprised the case group. In the second part of the study, the case group was included in a parallel cohort. A total of 320 patients were assessed for eligibility, and 135 patients were enrolled. Double blinding was performed, and neither the patients nor the care providers knew the measured parameters. The primary outcome was the detection of between-group changes in local TEPs over the follow-up period. The secondary outcome was the appearance of OM grades II, III, or IV and the predictive value of local TEPs in determining the incidence of OM after RT. The variables, impedance module, resistance, reactance, phase angle, and capacitance, were analyzed by the receiver operator curves (ROC). The case and control groups did not differ in demographic and clinical characteristics. Radiation therapy increased the local impedance module, resistance, reactance, and phase angle and reduced the local tissue capacitance in both groups. Evaluation of TEPs in the first week of RT correlated with the development of OM lesions during cancer therapy. ROC analysis showed that local impedance module and resistance presented higher specificity than did other parameters in predicting OM. In conclusion, local tissue electrical parameters measured at the first RT week can be useful tools to predict oral mucositis.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41598-020-66351-9

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Local tissue electrical parameters predict oral mucositis in HNSCC patients A diagnostic accuracy double-blind, randomized controlled trial.pdf
Tamanho:
1.91 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG