Zika virus disrupts molecular fingerprinting of human neurospheres

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dc.creatorPatricia P. Garcez
dc.creatorGabriela Vitória
dc.creatorPatricia C. Sequeira
dc.creatorJaroslaw Sochacki
dc.creatorRenato Santana de Aguiar
dc.creatorHellen Thais Fuzii
dc.creatorAna Maria Bispo de Filippis
dc.creatorJoão Lídio da Silva Gonçalves Vianez Júnior
dc.creatorAmilcar Tanuri
dc.creatorDaniel Martins de Souza
dc.creatorStevens K. Rehen
dc.creatorJuliana Minardi Nascimento
dc.creatorJanaina Mota de Vasconcelos
dc.creatorRodrigo Madeiro da Costa
dc.creatorRodrigo Delvecchio
dc.creatorPablo Trindade
dc.creatorErick Correia Loiola
dc.creatorLuiza M. Higa
dc.creatorJuliana Silva Cassoli
dc.date.accessioned2023-07-15T00:13:44Z
dc.date.accessioned2025-09-09T00:57:40Z
dc.date.available2023-07-15T00:13:44Z
dc.date.issued2017
dc.identifier.doi10.1038/srep40780 (2017)
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/56348
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.subjectVírus da Zika
dc.subjectMicrocefalia
dc.subjectFeto - Cerebro - Anomalias
dc.subject.otherZika virus
dc.subject.otherMicrocephaly
dc.subject.otherBrain
dc.titleZika virus disrupts molecular fingerprinting of human neurospheres
dc.typeArtigo de periódico
local.citation.epage10
local.citation.spage1
local.citation.volume7
local.description.resumoZika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of ZIKV to human brain development are still not fully understood. Here we describe alterations in human neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus that is circulating in Brazil. Combining proteomics and mRNA transcriptional profiling, over 500 proteins and genes associated with the Brazilian ZIKV infection were found to be differentially expressed. These genes and proteins provide an interactome map, which indicates that ZIKV controls the expression of RNA processing bodies, miRNA biogenesis and splicing factors required for self-replication. It also suggests that impairments in the molecular pathways underpinning cell cycle and neuronal differentiation are caused by ZIKV. These results point to biological mechanisms implicated in brain malformations, which are important to further the understanding of ZIKV infection and can be exploited as therapeutic potential targets to mitigate it.
local.identifier.orcidhttps://orcid.org/0000-0002-9107-1335
local.identifier.orcidhttps://orcid.org/0000-0003-4415-3837
local.identifier.orcidhttps://orcid.org/0000-0002-0616-3543
local.identifier.orcidhttps://orcid.org/0000-0002-9815-9022
local.identifier.orcidhttps://orcid.org/0000-0002-9420-6143
local.identifier.orcidhttps://orcid.org/0000-0002-1117-9099
local.identifier.orcidhttps://orcid.org/0000-0003-4216-9501
local.identifier.orcidhttps://orcid.org/0000-0003-3126-4984
local.identifier.orcidhttps://orcid.org/0000-0001-5646-8858
local.identifier.orcidhttps://orcid.org/0000-0002-2951-3964
local.identifier.orcidhttps://orcid.org/0000-0001-5953-7054
local.identifier.orcidhttps://orcid.org/0000-0002-7926-795X
local.identifier.orcidhttps://orcid.org/0000-0002-2174-6309
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/srep40780#Sec3

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