Novel symmetrical 1,4-Disubstituted-bis-1,2,3-Triazoles: synthesis by double CuAAC and cytotoxicity evaluation

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dc.creatorWallace Junio Reis
dc.creatorPaulo Otávio Lourenço Moreira
dc.creatorRosemeire Brondi Alves
dc.creatorHeloísa Helena Marques Oliveira
dc.creatorLuciana M. Silva
dc.creatorFernando de Pilla Varotti
dc.creatorRossimiriam Pereira de Freitas
dc.date.accessioned2024-07-15T18:15:30Z
dc.date.accessioned2025-09-08T23:06:51Z
dc.date.available2024-07-15T18:15:30Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttp://dx.doi.org/10.2174/1568026618666181022124847
dc.identifier.issn1873-4294
dc.identifier.urihttps://hdl.handle.net/1843/70586
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCurrent Topics in Medicinal Chemistry
dc.rightsAcesso Restrito
dc.subjectTriazóis
dc.subjectApoptose
dc.subjectCitotoxidade de mediação celular
dc.subjectAgentes antineoplásicos
dc.subjectQuímica farmacêutica
dc.subject.otherSymmetrical bis-1, 2, 3-triazoles
dc.subject.otherBis-azides
dc.subject.otherDouble CuAAC
dc.subject.otherCytotoxicity
dc.subject.otherBrdU
dc.subject.otherApoptosis
dc.subject.otherCancer
dc.titleNovel symmetrical 1,4-Disubstituted-bis-1,2,3-Triazoles: synthesis by double CuAAC and cytotoxicity evaluation
dc.typeArtigo de periódico
local.citation.epage1482
local.citation.issue17
local.citation.spage1475
local.citation.volume18
local.description.resumoBackground: A series of symmetrical 1,4-disubstituted bis-1,2,3-triazoles was prepared by double copper catalyzed Azide-alkyne Cycloaddition (CuAAC) from aliphatic bis-azides and a tetraethylene glycol bis-azide derivative. The eighteen novel compounds were evaluated in vitro for their cytotoxic activity against two human tumor cell lines: Human breast adenocarcinoma (MDA-MB 231) and ovarian adenocarcinoma (TOV-21G). Results and Conclusion: The results of colorimetric MTT assays showed that compounds 4j and 4q exhibited a better selectivity index and cell viability comparable with the standard drug doxorubicin. These compounds induced apoptosis in both tested cell lines, as assessed by BrdU assay. The results suggest that these structurally simple compounds may be promising prototypes for antitumoral agents.
local.identifier.orcidhttps://orcid.org/0000-0001-7337-6488
local.identifier.orcidhttps://orcid.org/0000-0002-6250-6854
local.identifier.orcidhttps://orcid.org/0000-0003-0546-2549
local.identifier.orcidhttps://orcid.org/0000-0002-5369-3598
local.identifier.orcidhttps://orcid.org/0000-0002-2939-7780
local.identifier.orcidhttps://orcid.org/0000-0001-6974-3724
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.eurekaselect.com/article/93875

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