Immune microenvironment and evasion mechanisms in adenoid cystic carcinomas of salivary glands

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dc.creatorCarla Mosconi
dc.creatorAline Carvalho Batista
dc.creatorJosé Alcides Almeida de Arruda
dc.creatorAna Caroline Rodrigues de Farias
dc.creatorGabriella Alves Quixabeira Oliveira
dc.creatorHenrique Moura de Paula
dc.creatorFelipe Paiva Fonseca
dc.creatorRicardo Alves Mesquita
dc.creatorTarcília Aparecida da Silva
dc.creatorElismauro Francisco Mendonça
dc.date.accessioned2023-11-16T21:05:46Z
dc.date.accessioned2025-09-09T00:56:47Z
dc.date.available2023-11-16T21:05:46Z
dc.date.issued2019-01
dc.identifier.doihttps://doi.org/10.1016/j.oraloncology.2018.11.028
dc.identifier.issn13688375
dc.identifier.urihttps://hdl.handle.net/1843/61012
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Oncology
dc.rightsAcesso Restrito
dc.subjectCarcinoma
dc.subjectCarcinoma, adenoid cystic
dc.subjectHead and neck neoplasms
dc.subjectImmunohistochemistry
dc.subjectMouth Neoplasms
dc.subjectSalivary glands
dc.subjectAssociation
dc.subjectRecurrence
dc.subjectProteins
dc.subject.otherMicrobiologia oral
dc.subject.otherMecanismos de evasão
dc.subject.otherCisto adenóide
dc.subject.otherCarcinomas de glândulas salivares
dc.titleImmune microenvironment and evasion mechanisms in adenoid cystic carcinomas of salivary glands
dc.typeArtigo de periódico
local.citation.epage101
local.citation.spage95
local.citation.volume88
local.description.resumoObjectives: The objective of the present study was to investigate the expression of immune checkpoints (PD-L1, PD-L2, PD-1 and CTLA-4), immune inhibitory molecule HLA-G, markers of tumor-infiltrating lymphocytes (TIL) and dendritic cells (DC), as well as its association with clinicopathological features of adenoid cystic carcinomas (ACC) of the salivary glands. Materials and methods: Thirty-six samples from patients with ACC were analyzed immunohistochemically for the expression of PD-L1, PD-L2, PD-1, CTLA-4, HLA-G, CD8, GrB, CD1a and CD83. Positivity of HLA-G, PD-L1 and PD-L2 expression was defined by cut-offs values. CD8+ TIL was measured semiquantitatively and also using cut-off values obtained by the ROC curve considering recurrence of the lesion. Results: ACC showed low CD8+, GrB+ TIL, CD1a and CD83 populations, as well as scarce positivity for CTLA-4 and PD-1. In contrast, PD-L2 and HLA-G expression was increased, while no PD-L1 expression was detected. Interestingly, cases with lower CD8+ TIL density presented greater recurrence rates. Conclusion: Our findings suggest that the ACC microenvironment exhibits low immunogenicity, represented by low TIL and DC density. Moreover, there seems to be activation of the immune inhibitory proteins/PD-L2 and HLA-G, a scenario that may favor tumor escape from the immune system and partially explain the poor prognosis of ACC.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1368837518304482?via%3Dihub

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