High-intensity interval training improves cerebellar antioxidant capacity without affecting cognitive functions in rats

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dc.creatorDaniel Almeida Freitas
dc.creatorEtel Rocha Vieira
dc.creatorRicardo Augusto Leoni de Sousa
dc.creatorBruno Alvarenga Soares
dc.creatorArthur Rocha Gomes
dc.creatorBruna Caroline Chaves Garcia
dc.creatorRicardo Cardoso Cassilhas
dc.creatorVanessa Amaral Mendonça
dc.creatorAna Cristina Resende Camargos
dc.creatorJosé Antonio Michell de Gregorio
dc.creatorAna Cristina Rodrigues Lacerda
dc.creatorHércules Ribeiro Leite
dc.date.accessioned2022-05-13T16:46:01Z
dc.date.accessioned2025-09-09T00:22:55Z
dc.date.available2022-05-13T16:46:01Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.1016/j.bbr.2019.112181
dc.identifier.issn0166-4328
dc.identifier.urihttps://hdl.handle.net/1843/41648
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBehavioural Brain Research
dc.rightsAcesso Restrito
dc.subjectExercício físico
dc.subjectCerebelo
dc.subjectInflamação
dc.subjectMemória
dc.subjectCognição
dc.subject.otherPhysical exercise
dc.subject.otherCerebellum
dc.subject.otherInflammation
dc.subject.otherMemory
dc.subject.otherCognition
dc.titleHigh-intensity interval training improves cerebellar antioxidant capacity without affecting cognitive functions in rats
dc.typeArtigo de periódico
local.citation.epage7
local.citation.spage1
local.citation.volume376
local.description.resumoHigh-intensity interval training (HIIT) is associated with better physical performance, but there is limited information about the effects of HIIT on redox state of cerebellar tissue, cerebral cortex, and cognition. The aim of this study was to evaluate the effects of HIIT on redox state parameters in cerebellar tissue, cerebral cortex, and cognitive function of Wistar rats. Forty-three young male Wistar rats were housed under controlled environmental conditions with food, and water ad libitum. Animals were assigned to HIIT or Non-trained groups. HIIT protocol was performed during six weeks. Speed was determined through the assesstment of the maximum oxygen consumption (VO2max). HIIT consisted of short bouts (1 min) running on a treadmill at 10° inclination (85–100% of VO2max) with 2 min of active recovery (60% of VO2max, without inclination). Non-trained group was daily exposed to a disconnected treadmill for the same amount of time as HITT group. Both groups were submitted to the open field, and novel object recognition tasks after six weeks. Malondialdehyde concentration (MDA), superoxide dismutase (SOD) activity, and non-enzymatic antioxidant capacity (FRAP) were quantified to determine the redox state. HIIT presented increased levels of MDA, SOD, and FRAP (p < 0.05) in the cerebellar tissue, but no differences were seen in cerebral cortex. These results indicated an improved antioxidant capacity, despite increased MDA levels in the cerebellar tissue. Both groups did not present impairment in locomotor activity, development of anxious behavior or cognitive decline. HIIT enhanced the antioxidant defenses on cerebellar tissue with no deleterious effects on rats’ cognition.
local.identifier.orcidhttps://orcid.org/ 0000-0001-6908-7237
local.identifier.orcidhttps://orcid.org/ 0000-0003-2622-032X
local.identifier.orcidhttps://orcid.org/ 0000-0002-1709-3747
local.identifier.orcidhttps://orcid.org/ 0000-0002-2494-3113
local.identifier.orcidhttps://orcid.org/0000-0001-7798-1247
local.identifier.orcidhttps://orcid.org/0000-0001-6970-2551
local.identifier.orcidhttps://orcid.org/0000-0002-1696-6091
local.identifier.orcidhttp://orcid.org/0000-0003-2719-4231
local.identifier.orcidhttp://orcid.org/0000-0001-5366-3754
local.identifier.orcidhttps://orcid.org/0000-0001-8977-8131
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0166432819304735?via%3Dihub#fig0010

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