Newborn skin reflection: proof of concept for a new approach for predicting gestational age at birth. a cross-sectional study

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dc.creatorZilma Silveira Nogueirareis
dc.creatorGabriela Luiza Nogueira Vitral
dc.creatorIngrid Michelle Fonseca de Souza
dc.creatorMaria Albertina Santiago Rego
dc.creatorRodney Nascimento Guimaraes
dc.date.accessioned2023-06-28T22:57:33Z
dc.date.accessioned2025-09-08T23:27:51Z
dc.date.available2023-06-28T22:57:33Z
dc.date.issued2017-09-20
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0184734
dc.identifier.issn19326203
dc.identifier.urihttps://hdl.handle.net/1843/55520
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPLOS ONE
dc.rightsAcesso Aberto
dc.subjectIdade gestacional
dc.subjectTerapia Intensiva Neonatal
dc.subjectIntervalos de Confiança
dc.subject.otherGestational age
dc.subject.otherNeonatal intensive care
dc.subject.otherConfidence interval
dc.titleNewborn skin reflection: proof of concept for a new approach for predicting gestational age at birth. a cross-sectional study
dc.typeArtigo de periódico
local.citation.epage17
local.citation.issue9
local.citation.spage1159
local.citation.volume12
local.description.resumoCurrent methods to assess the gestational age during prenatal care or at birth are a global challenge. Disadvantages, such as low accessibility, high costs, and imprecision of clinical tests and ultrasonography measurements, may compromise health decisions at birth, based on the gestational age. Newborns’ organs and tissues can indirectly indicate their physical maturity, and we hypothesized that evolutionary changes in their skin, detected using an optoelectronic device meter, may aid in estimating the gestational age. This study analyzed the feasibility of using newborn skin reflectance to estimate the gestational age at birth noninvasively. Methods and findings A cross-sectional study evaluated the skin reflectance of selected infants, preferably premature, at birth. The first-trimester ultrasound was the reference for gestational age. A prototype of a new noninvasive optoelectronic device measured the backscattering of light from the skin, using a light emitting diode at wavelengths of 470 nm, 575 nm, and 630 nm. Univar iate and multivariate regression analysis models were employed to predict gestational age, combining skin reflectance with clinical variables for gestational age estimation. The gesta tional age at birth of 115 newborns from 24.1 to 41.8 weeks of gestation correlated with the light at 630 nm wavelength reflectance 3.3 mm/6.5 mm ratio distant of the sensor, at the forearm and sole (Pearson’s correlation = 0.505, P < 0.001 and 0.710, P < 0.001, respectively). The best-combined variables to predict the gold standard gestational age at birtwas the skin reflectance at wavelengths of 630 nm and 470 nm in combination with birth weight, phototherapy, and adjusted to include incubator stay, and sex (R2 = 0.828, P <0.001). The main limitation of the study is that it was very specific to the premature population we studied and needs to be studied in a broader spectrum of newborns.Conclusions A novel automated skin reflectometer device, in combination with clinical variables, was able to predict the gestational age and could be useful when the information is in doubt or is unknown. Multivariable predictive models associated the skin reflectance with easy to obtain clinical parameters, at the birth scenario. External validation needs to be proven in an actual population with the real incidence of premature infants.
local.identifier.orcidhttps://orcid.org/0000-0001-5689-3870
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184734

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