Neural correlates of hallucinations in bipolar disorder

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dc.creatorMaila de C. Neves
dc.creatorDante G. Duarte
dc.creatorMaicon R. Albuquerque
dc.creatorRodrigo Nicolato
dc.creatorFernando Silva Neves
dc.creatorFábio L. de Souza-Duran
dc.creatorGeraldo Busatto
dc.creatorHumberto Corrêa da Silva Filho
dc.date.accessioned2023-07-12T20:59:37Z
dc.date.accessioned2025-09-08T23:24:43Z
dc.date.available2023-07-12T20:59:37Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doi10.1590/1516-4446-2014-1640
dc.identifier.issn1809452X
dc.identifier.urihttps://hdl.handle.net/1843/56146
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista Brasileira de Psiquiatria
dc.rightsAcesso Aberto
dc.subjectTranstorno Bipolar
dc.subjectAlucinações
dc.subject.otherBipolar disorder
dc.subject.otherHallucinations
dc.subject.otherSalience network
dc.subject.otherVoxel-based morphometry
dc.titleNeural correlates of hallucinations in bipolar disorder
dc.typeArtigo de periódico
local.citation.epage5
local.citation.issue1
local.citation.spage1
local.citation.volume38
local.description.resumoObjective: Approximately one-half of all patients affected by bipolar disorder present with psychotic features on at least one occasion. Several studies have found that alterations in the activity of mesolimbic and prefrontal regions are related to aberrant salience in psychotic patients. The aim of the present study was to investigate the structural correlates of a history of hallucinations in a sample of euthymic patients with bipolar I disorder (BD-I).Methods: The sample consisted of 21 euthymic patients with BD-I and no comorbid axis I DSM-IV-TR disorders. Voxel based morphometry (VBM) was used to compare patients with and without a lifetime history of hallucinations. Preprocessing was performed using the Diffeomorphic Anatomical Registration through Exponentiated Lie Algebra (DARTEL) algorithm for VBM in SPM8. Images were processed using optimized VBM. Results: The main finding of the present study was a reduction in gray matter volume in the right posterior insular cortex of patients with BD-I and a lifetime history of hallucinations, as compared to subjects with the same diagnosis but no history of hallucinations. Conclusions: This finding supports the presence of abnormalities in the salience network in BD patients with a lifetime history of hallucinations. These alterations may be associated with an aberrant assignment of salience to the elements of one’s own experience, which could result in psychotic symptoms.
local.identifier.orcidhttps://orcid.org/0000-0003-2757-1375
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE ESPORTES
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://doi:10.1590/1516-4446-2014-1640

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