Immunohistochemical study of TGF-β1 in oral leukoplakia and oral squamous cell carcinoma: correlations between clinicopathological factors and overall survival

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dc.creatorVivian Petersen Wagner
dc.creatorPaula Rodrigues Cardoso
dc.creatorJean Nunes dos Santos
dc.creatorLuize Meurer
dc.creatorPablo Augustin Vargas
dc.creatorFelipe Paiva Fonseca
dc.creatorVinicius Coelho Carrard
dc.creatorManoela Domingues Martins
dc.date.accessioned2023-09-25T20:44:54Z
dc.date.accessioned2025-09-09T01:04:38Z
dc.date.available2023-09-25T20:44:54Z
dc.date.issued2017-10
dc.identifier.doi10.1097/PAI.0000000000000355
dc.identifier.issn15412016
dc.identifier.urihttps://hdl.handle.net/1843/58912
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofApplied Immunohistochemistry & Molecular Morphology
dc.rightsAcesso Restrito
dc.subjectCarcinoma
dc.subjectTransforming growth factor beta 1
dc.subjectLeukoplakia
dc.subjectAssociation
dc.subjectImmunohistochemistry
dc.subject.othernome revista Applied immunohistochemistry & molecular morphology
dc.titleImmunohistochemical study of TGF-β1 in oral leukoplakia and oral squamous cell carcinoma: correlations between clinicopathological factors and overall survival
dc.typeArtigo de periódico
local.citation.epage659
local.citation.issue9
local.citation.spage651
local.citation.volume25
local.description.resumoThe aim of the present study was to analyze transforming growth factor β1 (TGF-β1) expression in cases of leukoplakia and oral squamous cell carcinoma (OSCC) and to correlate these expression profiles with proliferative labeling index, clinicopathologic factors, and clinical outcome. Clinical data for 24 cases of leukoplakia and 87 cases of OSCC were retrieved from medical records. OSCC tissues were included into tissue microarray blocks and sections of normal mucosa, leukoplakia, and OSCC tissue microarray's were prepared on slides. Immunohistochemistry was used to detect expression of TGF-β1 and Ki67. The expression of TGF-β1 and Ki67 were significantly increased from normal mucosa, through leukoplakia to OSCC. High expression of TGF-β1 correlated with an increase in proliferative labeling index. No association between TGF-β1 expression and the clinicopathologic factors examined was observed. Expression of TGF-β1 also did not associate with clinical outcome in either of groups. Our results suggest that changes in TGF-β1 are associated with the progression of oral carcinogenesis
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://journals.lww.com/appliedimmunohist/fulltext/2017/10000/immunohistochemical_study_of_tgf__1_in_oral.9.aspx

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