N-Methyl-d-Aspartate (NMDA) receptor blockade prevents neuronal death induced by Zika Virus infection

Página do item simplificado
dc.creatorVivian V. Costa
dc.creatorJuliana L. Del Sarto
dc.creatorRebeca F. Rocha
dc.creatorFlavia R. Silva
dc.creatorJuliana G. Doria
dc.creatorIsabella G. Olmo
dc.creatorRafael E. Marques
dc.creatorCelso M. Queiroz Junior
dc.creatorGiselle Foureaux
dc.creatorJulia Maria S. Araújo
dc.creatorAllysson Cramer
dc.creatorAna Luíza C. V. Real
dc.creatorLucas S. Ribeiro
dc.creatorSilvia I. Sardi
dc.creatorAnderson J. Ferreira
dc.creatorFabiana S. Machado
dc.creatorAntônio C. de Oliveira
dc.creatorAntônio L. Teixeira
dc.creatorHelder I. Nakaya
dc.creatorDanielle G. Souza
dc.creatorFabiola M. Ribeiro
dc.creatorMauro M. Teixeira
dc.date.accessioned2025-01-20T23:42:49Z
dc.date.accessioned2025-09-09T01:15:16Z
dc.date.available2025-01-20T23:42:49Z
dc.date.issued2017-05-03
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1128/mbio.00350-17
dc.identifier.issn2150-7511
dc.identifier.urihttps://hdl.handle.net/1843/79350
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofmBio
dc.rightsAcesso Aberto
dc.subjectVírus da Zika
dc.subjectMorte cerebral
dc.subject.otherNMDA receptor
dc.subject.otherZika virus
dc.subject.otherIntraocular pressure
dc.subject.otherMemantine
dc.subject.otherMicrogliosis
dc.subject.otherMouse model
dc.subject.otherNeuronal death
dc.titleN-Methyl-d-Aspartate (NMDA) receptor blockade prevents neuronal death induced by Zika Virus infection
dc.typeArtigo de periódico
local.citation.epage16
local.citation.issue2
local.citation.spage1
local.citation.volume8
local.description.resumoZika virus (ZIKV) infection is a global health emergency that causes significant neurodegeneration. Neurodegenerative processes may be exacerbated by N-methyl-d-aspartate receptor (NMDAR)-dependent neuronal excitoxicity. Here, we have exploited the hypothesis that ZIKV-induced neurodegeneration can be rescued by blocking NMDA overstimulation with memantine. Our results show that ZIKV actively replicates in primary neurons and that virus replication is directly associated with massive neuronal cell death. Interestingly, treatment with memantine or other NMDAR blockers, including dizocilpine (MK-801), agmatine sulfate, or ifenprodil, prevents neuronal death without interfering with the ability of ZIKV to replicate in these cells. Moreover, in vivo experiments demonstrate that therapeutic memantine treatment prevents the increase of intraocular pressure (IOP) induced by infection and massively reduces neurodegeneration and microgliosis in the brain of infected mice. Our results indicate that the blockade of NMDARs by memantine provides potent neuroprotective effects against ZIKV-induced neuronal damage, suggesting it could be a viable treatment for patients at risk for ZIKV infection-induced neurodegeneration.
local.identifier.orcidhttps://orcid.org/0000-0002-6561-8018
local.identifier.orcidhttps://orcid.org/0000-0002-0007-3280
local.identifier.orcidhttps://orcid.org/0000-0001-7042-9433
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://journals.asm.org/doi/epdf/10.1128/mbio.00350-17

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
N-Methyl-d-Aspartate (NMDA) receptor blockade prevents neuronal death induced by zika virus infection.pdf
Tamanho:
3.94 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG